chymostatin
chymostatin structure
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Common Name | chymostatin | ||
|---|---|---|---|---|
| CAS Number | 9076-44-2 | Molecular Weight | 607.701 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C31H41N7O6 | Melting Point | 276-278℃ | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Enabling Low Cost Biopharmaceuticals: A Systematic Approach to Delete Proteases from a Well-Known Protein Production Host Trichoderma reesei.
PLoS ONE 10 , e0134723, (2015) The filamentous fungus Trichoderma reesei has tremendous capability to secrete proteins. Therefore, it would be an excellent host for producing high levels of therapeutic proteins at low cost. Developing a filamentous fungus to produce sensitive therapeutic p... |
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Estrogen inhibits mast cell chymase release to prevent pressure overload-induced adverse cardiac remodeling.
Hypertension 65(2) , 328-34, (2015) Estrogen regulation of myocardial chymase and chymase effects on cardiac remodeling are unknown. To test the hypothesis that estrogen prevents pressure overload-induced adverse cardiac remodeling by inhibiting mast cell (MC) chymase release, transverse aortic... |
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Primacy of angiotensin converting enzyme in angiotensin-(1-12) metabolism.
Am. J. Physiol. Heart Circ. Physiol. 305(5) , H644-50, (2013) Angiotensin-(1-12) [ANG-(1-12)], a new member of the renin-angiotensin system, is recognized as a renin independent precursor for ANG II. However, the processing of ANG-(1-12) in the circulation in vivo is not fully established. We examined the effect of angi... |
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Contractility of placental vascular smooth muscle cells in response to stimuli produced by the placenta: roles of ACE vs. non-ACE and AT1 vs. AT2 in placental vessel cells.
Placenta 29(6) , 503-9, (2008) Our previously published work has shown that non-ACE angiotensin II (Ang II) generating system is dominate in the placenta and may play a critical role in regulation of placental vascular contractile function. In the present study, using a collagen gel contra... |
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The structure of chymostatin, a chymotrypsin inhibitor.
J. Antibiot. 26(11) , 625-46, (1973)
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Chaperone-mediated autophagy.
Methods Mol. Biol. 445 , 227-44, (2008) Chaperone-mediated autophagy (CMA) is the only type of autophagy in mammalian cells able to selectively degrade cytosolic proteins in lysosomes. CMA is maximally activated in response to stressors such as prolonged starvation, exposure to toxic compounds, or ... |
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Stem cell factor is responsible for the rapid response in mature mast cell density in the acutely stressed heart.
J. Mol. Cell. Cardiol. 53(4) , 469-74, (2012) In the abdominal aortocaval (AV) fistula model of heart failure, we have shown that the acute doubling of cardiac mature mast cell (MC) density involved the maturation, but not proliferation, of a resident population of immature cardiac MCs. An increase in st... |
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Interactions between angiotensin I and acetylcholine on rat left main bronchial rings.
Rev. Med. Chir. Soc. Med. Nat. Iasi. 110(1) , 186-91, (2006) Angiotensin (Ang) II is known to amplified bronchoconstriction induced by acetylcholine (ACh). On the other hand all the components of renin angiotensin system were located on lungs. Contractile effects of Ang I (the precursor of Ang II) and interactions betw... |
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Cathepsin G induces cell aggregation of human breast cancer MCF-7 cells via a 2-step mechanism: catalytic site-independent binding to the cell surface and enzymatic activity-dependent induction of the cell aggregation.
Mediators Inflamm. 2012 , 456462, (2012) Neutrophils often invade various tumor tissues and affect tumor progression and metastasis. Cathepsin G (CG) is a serine protease secreted from activated neutrophils. Previously, we have shown that CG induces the formation of E-cadherin-mediated multicellular... |
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Cordysobin, a novel alkaline serine protease with HIV-1 reverse transcriptase inhibitory activity from the medicinal mushroom Cordyceps sobolifera.
J. Biosci. Bioeng. 113(1) , 42-7, (2011) A novel serine protease, designated as cordysobin, was purified from dried fruiting bodies of the mushroom Cordyceps sobolifera. The isolation procedure utilized ion exchange chromatography on DEAE-cellulose and SP-Sepharose followed by gel filtration on Supe... |