GSK-J4
GSK-J4 structure
|
Common Name | GSK-J4 | ||
|---|---|---|---|---|
| CAS Number | 1373423-53-0 | Molecular Weight | 417.504 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 581.2±50.0 °C at 760 mmHg | |
| Molecular Formula | C24H27N5O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 305.3±30.1 °C | |
|
The TrxG Complex Mediates Cytokine Induced De Novo Enhancer Formation in Islets.
PLoS ONE 10 , e0141470, (2015) To better understand how β-cells respond to proinflammatory cytokines we mapped the locations of histone 3 lysine 4 monomethylation (H3K4me1), a post-translational histone modification enriched at active and poised cis-regulatory regions, in IFNγ, Il-1β, and ... |
|
|
New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome.
Hum. Mol. Genet. 23(24) , 6553-66, (2014) Cardio-facio-cutaneous (CFC) syndrome is one of the 'RASopathies', a group of phenotypically overlapping syndromes caused by germline mutations that encode components of the RAS-MAPK pathway. Germline mutations in BRAF cause CFC syndrome, which is characteriz... |
|
|
Histone demethylation maintains Prdm14 and Tsix expression and represses xIst in embryonic stem cells.
PLoS ONE 10 , e0125626, (2015) Epigenetic reprogramming is exemplified by the remarkable changes observed in cellular differentiation and X-chromosome inactivation (XCI) in mammalian female cells. Histone 3 lysine 27 trimethylation (H3K27me3) is a modification that suppresses gene expressi... |
|
|
PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T-Cell Trafficking in Colon Cancer.
Cancer Res. 76 , 275-82, (2016) Infiltration of tumors with effector T cells is positively associated with therapeutic efficacy and patient survival. However, the mechanisms underlying effector T-cell trafficking to the tumor microenvironment remain poorly understood in patients with colon ... |
|
|
Genome-wide association between Six4, MyoD, and the histone demethylase Utx during myogenesis.
FASEB J. 29 , 4738-55, (2015) Adult skeletal muscles can regenerate after injury, due to the presence of satellite cells, a quiescent population of myogenic progenitor cells. Once activated, satellite cells repair the muscle damage by undergoing myogenic differentiation. The myogenic regu... |
|
|
Neuronal activity controls Bdnf expression via Polycomb de-repression and CREB/CBP/JMJD3 activation in mature neurons.
Nat. Commun. 7 , 11081, (2016) It has been recently described that in embryonic stem cells, the expression of some important developmentally regulated genes is repressed, but poised for fast activation under the appropriate stimuli. In this work we show that Bdnf promoters are repressed by... |