Pramipexole dihydrochloride
Pramipexole dihydrochloride structure
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Common Name | Pramipexole dihydrochloride | ||
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| CAS Number | 104632-25-9 | Molecular Weight | 284.249 | |
| Density | N/A | Boiling Point | 378ºC at 760 mmHg | |
| Molecular Formula | C10H19Cl2N3S | Melting Point | 288-290ºC | |
| MSDS | USA | Flash Point | 182.4ºC | |
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Pramipexole reduces parkinsonian tremor induced by pilocarpine infusion in the rat striatum.
Pharmacol. Biochem. Behav. 131 , 1-5, (2015) Pramipexole is widely prescribed for the treatment of Parkinson's disease. This dopamine (DA) receptor agonist has a higher affinity for D3 over D2 receptors. We compared the effect of pramipexole to apomorphine, a non-specific DA receptor agonist, on the sup... |
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Alterations of BDNF and trkB mRNA expression in the 6-hydroxydopamine-induced model of preclinical stages of Parkinson's disease: an influence of chronic pramipexole in rats.
PLoS ONE 10(3) , e0117698, (2015) Our recent study has indicated that a moderate lesion of the mesostriatal and mesolimbic pathways in rats, modelling preclinical stages of Parkinson's disease, induces a depressive-like behaviour which is reversed by chronic treatment with pramipexole. The pu... |
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De novo expression of dopamine D2 receptors on microglia after stroke.
J. Cereb. Blood Flow Metab. 35 , 1804-11, (2015) Dopamine is the predominant catecholamine in the brain and functions as a neurotransmitter. Dopamine is also a potent immune modulator. In this study, we have characterized the expression of dopamine receptors on murine microglia. We found that cultured prima... |
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Bias analyses of preclinical and clinical D2 dopamine ligands: studies with immediate and complex signaling pathways.
J. Pharmacol. Exp. Ther. 352(3) , 480-93, (2015) G protein-coupled receptors (GPCRs) often activate multiple signaling pathways, and ligands may evoke functional responses through individual pathways. These unique responses provide opportunities for biased or functionally selective ligands to preferentially... |
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Combining a dopamine agonist and selective serotonin reuptake inhibitor for the treatment of depression: a double-blind, randomized pilot study.
J. Affect. Disord. 149(1-3) , 319-25, (2013) Antidepressants that act on two or more amine neurotransmitters may confer higher remission rates when first-line agents affecting a single neurotransmitter have failed. Pramipexole, a dopamine agonist, has antidepressant effects in patients with major depres... |
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Nucleus accumbens D2R cells signal prior outcomes and control risky decision-making.
Nature 531 , 642-6, (2016) A marked bias towards risk aversion has been observed in nearly every species tested. A minority of individuals, however, instead seem to prefer risk (repeatedly choosing uncertain large rewards over certain but smaller rewards), and even risk-averse individu... |