Levonorgestrel

Levonorgestrel Structure
Levonorgestrel structure
Common Name Levonorgestrel
CAS Number 6533-00-2 Molecular Weight 312.446
Density 1.1±0.1 g/cm3 Boiling Point 459.1±45.0 °C at 760 mmHg
Molecular Formula C21H28O2 Melting Point 239-241ºC
MSDS N/A Flash Point 195.4±21.3 °C

Progestagen-only oral contraceptives: a preliminary report of the action and clinical use of norgestrel and norethisterone.

Drugs 6(3) , 169-81, (1973)

Types of combined oral contraceptives used by US women.

Contraception 86(6) , 659-65, (2012)

We sought to estimate the prevalence of types of combined oral contraceptives (COCs) used among US women.We analyzed interview-collected data from 12,279 women aged 15-44 years participating in the National Survey of Family Growth, 2006-2010. Analyses focused...

Newer non-oral hormonal contraception.

BMJ 346 , f341, (2013)

Antimüllerian hormone levels decrease in women using combined contraception independently of administration route.

Fertil. Steril. 99(5) , 1305-10, (2013)

To compare the effects of continuous use of oral (OC), transdermal, and vaginal combined contraceptives on the pituitary-ovarian axis and inhibition of follicular development.Spin-off study of a prospective, randomized trial.University clinic.Forty-two of 54 ...

Recent combined hormonal contraceptives (CHCs) and the risk of thromboembolism and other cardiovascular events in new users.

Contraception 87(1) , 93-100, (2013)

Combined hormonal contraceptives (CHCs) place women at increased risk of venous thromboembolic events (VTEs) and arterial thrombotic events (ATEs), including acute myocardial infarction and ischemic stroke. There is concern that three recent CHC preparations ...

Inhibition of diacylglycerol-sensitive TRPC channels by synthetic and natural steroids.

PLoS ONE 7(4) , e35393, (2012)

TRPC channels are a family of nonselective cation channels that regulate ion homeostasis and intracellular Ca(2+) signaling in numerous cell types. Important physiological functions such as vasoregulation, neuronal growth, and pheromone recognition have been ...

Venous thrombosis in users of non-oral hormonal contraception: follow-up study, Denmark 2001-10.

BMJ 344 , e2990, (2012)

To assess the risk of venous thrombosis in current users of non-oral hormonal contraception.Historical national registry based cohort study.Four national registries in Denmark.All Danish non-pregnant women aged 15-49 (n=1,626,158), free of previous thrombotic...

Differences in prescription rates and odds ratios of antidepressant drugs in relation to individual hormonal contraceptives: a nationwide population-based study with age-specific analyses.

Eur. J. Contracept. Reprod. Health Care 17(2) , 106-18, (2012)

To examine, among young women, the association of individual hormonal contraceptives, within two broad groupings, with antidepressant therapy.In a nationwide register-based study, we examined the prescription rates of antidepressant drugs in relation to indiv...

A novel approach to the quantitative detection of anabolic steroids in bovine muscle tissue by means of a hybrid quadrupole time-of-flight-mass spectrometry instrument.

J. Chromatogr. A. 1360 , 229-39, (2014)

In recent years, the analysis of veterinary drugs and growth-promoting agents has shifted from target-oriented procedures, mainly based on liquid chromatography coupled to triple-quadrupole mass spectrometry (LC-QqQ-MS), towards accurate mass full scan MS (su...

Impact of combined oral contraceptives containing ethinylestradiol on the liver microsomal metabolism.

Eur. J. Contracept. Reprod. Health Care 18(4) , 284-92, (2013)

To check whether currently used combined oral contraceptives (COCs) containing ethinylestradiol (EE) affect the liver microsomal metabolism.(13)C-methacetin breath test ((13)C-MBT) - a sensitive non-invasive probe of cytochrome P-450 1A2 activity - was perfor...