4-Deoxy pyridoxine hydrochloride
4-Deoxy pyridoxine hydrochloride structure
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Common Name | 4-Deoxy pyridoxine hydrochloride | ||
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| CAS Number | 148-51-6 | Molecular Weight | 189.64 | |
| Density | 1.201g/cm3 | Boiling Point | 414.1ºC at 760 mmHg | |
| Molecular Formula | C8H12ClNO2 | Melting Point | 274°C(dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 204.2ºC | |
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Effect of combination of deoxypyridoxine with known anti-proliferative or immunosuppressive agents on lymphocyte serine hydroxymethyltransferase.
Postgrad. Med. J. 70 Suppl 1 , S89-92, (1994) Measurements of serine hydroxymethyltransferase (SHMT) in resting lymphocyte cultures showed that the level of activity of this enzyme is very low. Under the influence of mitogenic stimuli serine hydroxymethyltransferase activity is induced 5-20-fold. Additio... |
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Intracellular predominance of the pyridoxal 5'-phosphate form of aspartate aminotransferase in Escherichia coli B and reversible transformation of this form by extracellular substances.
Biochimie 71(4) , 427-38, (1989) The intracellular proportion of the pyridoxal 5'-phosphate form of aspartate aminotransferase to the total enzyme in E. coli B cells was determined by a newly devised method, dependent on selective inactivation of the intracellular pyridoxal 5'-phosphate form... |
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Effects of DL-alpha-difluoromethylornithine, 4-deoxypyridoxine and methylglyoxal bis(guanylhydrazone) on allograft prolongation.
Life Sci. 48(3) , 225-35, (1991) DL-alpha-difluoromethylornithine (DFMO), 4-deoxypyridoxine (4-DOP), and methylglyoxal bis (guanylhydrazone) (MGBG) were tested as inhibitors of acute skin graft rejection. Proximal full thickness tail skins were exchanged between C57BL/6 and Balb/C mice. Dist... |
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Inhibitory effect of deoxypyridoxine on the action of certain mitogenic factors.
Immunopharmacol. Immunotoxicol. 11(4) , 657-66, (1989) We studied the effect of pyridoxine deficiency state on the responses of human lymphocytes to certain mitogenic factors. Deoxypyridoxine (DB6), a potent pyridoxine antagonist, considerably inhibited Bromodeoxyuridine (BrdU) incorporation into the newly synthe... |
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MCP-1 and MIP-2 response in Trichinella spiralis infected mice treated with 4-deoxypyridoxine (4-DPD).
Immunol. Lett. 83(1) , 31-7, (2002) Chemokines are involved in a number of pathophysiological conditions, such as inflammatory processes and are divided in two major subfamilies, C-X-C and C-C chemokines. The C-C chemokines are monocyte chemotactic protein 1-2-3-4-5, while C-X-C chemokines incl... |
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IgG, IgG1 and IgM response in Trichinella spiralis-infected mice treated with 4-deoxypirydoxine or fed a Vitamin B6-deficient diet.
Mol. Cell Biochem. 194(1-2) , 47-52, (1999) The aim of this study was to investigate the effect of pyridoxine (Vitamin B6) deficiency on the immunological response of BALB/c mice infected with the parasite T. spiralis. Specific anti-parasite IgM and IgG immunoglobulins were detected by ELISA method in ... |
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Vitamin B6 antagonists alter the function and ultrastructure of mice endothelial cells.
J. Nutr. Sci. Vitaminol. 46(4) , 149-53, (2000) Vitamin B6, is necessary for normal membrane function and stability. Here we studied both the function and ultrastructure of aortic and arterial endothelial cells (ECs) in vitamin B6 deficient mice induced by vitamin B6 antagonists, 4-deoxypyridoxine x HCl (d... |
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4-Deoxypyridoxine inhibits chronic granuloma formation induced by potassium permanganate in vivo.
Mol. Cell Biochem. 136(1) , 59-63, (1994) 4-Deoxypyridoxine (4-DPD) is a potent antagonist of Vitamin B6 coenzyme which inhibits IL-1, lymphocyte proliferation and has demonstrated that tolerance to skin grafts can be induced by administering splenic cells to pyridoxine-deficient mice. Chronic inflam... |
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Vitamin B6-deficient diet plus 4-deoxypyridoxine (4-DPD) reduces the inflammatory response induced by T. spiralis in diaphragm, masseter and heart muscle tissue of mice.
Mol. Cell Biochem. 197(1-2) , 79-85, (1999) Animals fed diets deficient in vitamin B6 develop microcytic anemia, alterations of growth, and other pathologies. 4-deoxypirydoxine is a potent antagonist of vitamin B6 coenzyme which depresses IL-1, TNF and IL-6 and has anti-inflammatory properties. The aim... |
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[Histopathological study of isolated isovolumetric rat heart: effects of isoprenaline and 4-deoxypyridoxine].
Cell Mol. Biol. 34(6) , 685-92, (1988)
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