N-AcetylprocainaMide hydrochloride
N-AcetylprocainaMide hydrochloride structure
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Common Name | N-AcetylprocainaMide hydrochloride | ||
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| CAS Number | 34118-92-8 | Molecular Weight | 313.82 | |
| Density | N/A | Boiling Point | 500ºC at 760mmHg | |
| Molecular Formula | C15H24ClN3O2 | Melting Point | 184-186ºC(lit.) | |
| MSDS | USA | Flash Point | 256.2ºC | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Phase II metabolism in human skin: skin explants show full coverage for glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation.
Drug Metab. Dispos. 43(1) , 126-39, (2014) Although skin is the largest organ of the human body, cutaneous drug metabolism is often overlooked, and existing experimental models are insufficiently validated. This proof-of-concept study investigated phase II biotransformation of 11 test substrates in fr... |
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Drug-herb interaction: effect of St John's wort on bioavailability and metabolism of procainamide in mice.
Arch. Pathol. Lab. Med. 131(7) , 1094-8, (2007) St John's wort induces the activity of the cytochrome P450 enzyme system causing treatment failure because of increased metabolism of many drugs. Procainamide is metabolized by a different pathway to N-acetyl procainamide.To study St John's wort-procainamide ... |
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Application of computer-assisted radiotelemetry in the pharmacokinetic and pharmacodynamic modeling of procainamide and N-acetylprocainamide.
J. Pharm. Sci. 85(6) , 595-9, (1996) The cardiovascular pharmacodynamics (PD) of procainamide and N-acetylprocainamide have not been well characterized in small rodents without the presence of anesthesia or restraint. This study was undertaken to examine the pharmacokinetics (PK) and PD relation... |
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The discordant influences of infarct healing on the electrophysiologic effects of procainamide and N-acetylprocainamide.
J. Pharmacol. Exp. Ther. 273(1) , 315-9, (1995) Ischemic zone refractoriness and conduction delay respond differently to infarct healing and, hypothetically, may exert discordant influences on the electrophysiologic action of different classes of antiarrhythmic drugs. This study evaluated the influence of ... |
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Pharmacokinetic and pharmacodynamic comparisons of twice daily and four times daily formulations of procainamide in patients with frequent ventricular premature depolarization.
J. Clin. Pharmacol. 36(7) , 623-33, (1996) A study was conducted to evaluate the pharmacokinetics of procainamide and its active metabolite, N-acetylprocainamide (NAPA), as a function of dose and formulation and to characterize the relationship between ventricular premature depolarization (VPD) rate a... |
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Improved high-performance liquid chromatographic assay for the determination of procainamide and its N-acetylated metabolite in plasma: application to a single-dose pharmacokinetic study.
J. Chromatogr. Sci. 36(1) , 49-54, (1998) An improved high-performance liquid chromatographic assay for the determination of procainamide and N-acetylprocainamide (NAPA) at concentrations observed up to 32 h after a single oral dose administration of procainamide to human subjects is reported. Follow... |
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Inhibition of N-acetylation of procainamide and renal clearance of N-acetylprocainamide by para-aminobenzoic acid in humans.
J. Clin. Pharmacol. 35(9) , 902-10, (1995) Procainamide administration often results in excessively high serum N-acetylprocainamide (NAPA) concentrations and subtherapeutic serum procainamide concentrations. Inhibition of N-acetylation of procainamide may prevent accumulation of excessive NAPA while m... |
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Multicenter evaluation of the Abbott AxSYM procainamide and N-acetylprocainamide assays: comparison with Abbott TDx/TDxFLx, Syva EMIT 2000, DuPont ACA, and HPLC methods.
Clin. Biochem. 31(1) , 55-8, (1998)
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Effect of age, gender, and race on steady state procainamide pharmacokinetics after administration of procanbid sustained-release tablets.
Ther. Drug Monit. 20(1) , 73-7, (1998) Procainamide hydrochloride is a Class 1A antiarrhythmic agent administered intravenously or orally for treatment of symptomatic ventricular premature depolarizations (VPD), nonsustained ventricular tachycardia, and life-threatening ventricular arrhythmias. A ... |