anacardic acid
anacardic acid structure
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Common Name | anacardic acid | ||
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| CAS Number | 16611-84-0 | Molecular Weight | 348.519 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 474.8±33.0 °C at 760 mmHg | |
| Molecular Formula | C22H36O3 | Melting Point | 90-91℃ | |
| MSDS | Chinese USA | Flash Point | 255.1±21.9 °C | |
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Acetylation mediates Cx43 reduction caused by electrical stimulation.
J. Mol. Cell. Cardiol. 87 , 54-64, (2015) Communication between cardiomyocytes depends upon gap junctions (GJ). Previous studies have demonstrated that electrical stimulation induces GJ remodeling and modifies histone acetylase (HAT) and deacetylase (HDAC) activities, although these two results have ... |
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Genotoxic and cytostatic effects of 6-pentadecyl salicylic anacardic acid in transformed cell lines and peripheral blood mononuclear cells.
Mutat. Res. Genet. Toxicol. Environ. Mutagen. 777 , 43-53, (2015) In Mexico, as in many other countries, traditional medicine is used for the treatment of several diseases. In particular, Amphipterygium adstringens infusion is used for gastritis, gastric ulcers, and gastric cancer. Extracts from this tree have microbicidal ... |
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Ehrlichia chaffeensis exploits host SUMOylation pathways to mediate effector-host interactions and promote intracellular survival.
Infect. Immun. 82(10) , 4154-68, (2014) Ehrlichia chaffeensis is an obligately intracellular Gram-negative bacterium that selectively infects mononuclear phagocytes. We recently reported that E. chaffeensis utilizes a type 1 secretion (T1S) system to export tandem repeat protein (TRP) effectors and... |
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Effects of natural nuclear factor-kappa B inhibitors on anticancer drug efflux transporter human P-glycoprotein.
Biomed. Pharmacother. 70 , 140-5, (2015) Drug efflux transporter P-glycoprotein plays an important role in cancer chemotherapy. The nuclear factor-κB (NF-κB) transcription factors play critical roles in development and progression of cancer. In this study, the effects of natural compounds that can i... |
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A novel pyrido-thieno-pyrimidine derivative activates p53 through induction of phosphorylation and acetylation in colorectal cancer cells.
Int. J. Oncol. 46(1) , 342-50, (2014) The tumor suppressor p53 plays a key role in regulation of the cell cycle, apoptosis and senescence in response to various stresses. We screened a library of 7920 chemical compounds for the p53 activator and identified N-[2-(dimethylamino)ethyl]-2,3-dimethyl-... |
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Discovery of protein disulfide isomerase P5 inhibitors that reduce the secretion of MICA from cancer cells.
ChemBioChem. 15(11) , 1599-606, (2014) In order to regulate the activity of P5, which is a member of the protein disulfide isomerase family, we screened a chemical compound library for P5-specific inhibitors, and identified two candidate compounds (anacardic acid and NSC74859). Interestingly, anac... |
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Acetylated histones contribute to the immunostimulatory potential of neutrophil extracellular traps in systemic lupus erythematosus.
Clin. Exp. Immunol. 179(1) , 68-74, (2014) In addition to disturbed apoptosis and insufficient clearance of apoptotic cells, there is recent evidence for a role of neutrophils in the aetiopathogenesis of systemic lupus erythematosus (SLE). In response to various stimuli, neutrophils can rapidly releas... |
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6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site.
Eur. J. Med. Chem. 47 , 337-44, (2012) Histone acetyltransferases are important enzymes that regulate various cellular functions, such as epigenetic control of DNA transcription. Development of HAT inhibitors with high selectivity and potency will provide powerful mechanistic tools for the elucida... |
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Emerging Roles of Anacardic Acid and Its Derivatives: A Pharmacological Overview Hemshekhar, M., et al.
Basic Clin Pharmacol Toxicol. , doi: 10.1111/j.1742-7843.2011.00833.x., (2011)
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Probing the effect of intermolecular interaction and understanding the electrostatic moments of anacardic acid in the active site of p300 enzyme via DFT and charge density analysis.
J. Mol. Graph. Model. 34 , 57-66, (2012) A charge density analysis has been performed on gas phase and docked forms of anacardic acid molecule to understand its charge density distribution, electrostatic moments and the conformation in the active site of p300 enzyme. Here, we report the binding affi... |