Hematein
Hematein structure
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Common Name | Hematein | ||
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| CAS Number | 475-25-2 | Molecular Weight | 300.26300 | |
| Density | 1.77g/cm3 | Boiling Point | 753.1ºC at 760mmHg | |
| Molecular Formula | C16H12O6 | Melting Point | 180ºC | |
| MSDS | USA | Flash Point | 289ºC | |
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The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin-1 (PN-1) inhibition.
FASEB J. 28(11) , 4792-805, (2014) Serine proteases, serine protease inhibitors, and protease-activated receptors (PARs) are responsible for several human skin disorders characterized by impaired epidermal permeability barrier function, desquamation, and inflammation. In this study, we address... |
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Necrosis- and apoptosis-related Met cleavages have divergent functional consequences.
Cell Death Dis. 6 , e1769, (2015) Upon activation by its ligand hepatocyte growth factor/scatter factor, the receptor tyrosine kinase Met promotes survival, proliferation, and migration of epithelial cells during embryogenesis. Deregulated Met signaling can also promote cancer progression and... |
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The Effects of a Selective CK2 Inhibitor on Anti-glomerular Basement Membrane Glomerulonephritis in Rats.
Biol. Pharm. Bull. 38 , 1345-51, (2015) Protein kinase CK2 ("casein kinase II") is a protein serine/threonine kinase that plays critical roles in biological processes such as cell growth, cell cycle progression, and apoptosis. So far, we have identified that one catalytic isozyme of CK2, CK2α, is o... |
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Novel methodology for the extraction and identification of natural dyestuffs in historical textiles by HPLC-UV-Vis-ESI MS. Case study: chasubles from the Wawel Cathedral collection.
Anal. Bioanal. Chem 399(9) , 3241-51, (2011) High-performance liquid chromatography coupled with spectrophotometric and electrospray mass spectrometric detection (HPLC-UV-Vis-ESI MS) was used for characterization of natural dyes present in historical art works. The gradient program was developed for ide... |
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Effect of formalin pigment removal on peroxidase-antiperoxidase immunoperoxidase technique.
J. Clin. Pathol. 39(8) , 923-5, (1986)
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Localization of phospholipids in human catecholamine neurons with Baker's acid haematein.
J. Neurocytol. 18(5) , 593-7, (1989) Protein bodies in catecholamine neurons of the normal human brain contain arginine-rich proteins similar to those present in the core of Lewy bodies in Parkinsonian brains. Lewy bodies are known also to contain phospholipids in their core, demonstrable with B... |
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Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library.
BMC Cancer 9 , 135, (2009) Casein kinase 2 (CK2) is dysregulated in various human cancers and is a promising target for cancer therapy. To date, there is no small molecular CK2 inhibitor in clinical trial yet. With the aim to identify novel CK2 inhibitors, we screened a natural product... |
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Hematoxylin staining in quantitative DNA cytometry: an image analysis study.
Anal. Cell. Pathol. 9(4) , 257-68, (1995) The suitability of commercial and pure aluminum-hematein for quantitative DNA image cytometry was investigated. Cervical smears, breast cancer aspiration biopsies, and rabbit liver tissue imprints were stained with Mayer's and Harris' al-hematein with variabl... |
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A new use for an old method: the Woelcke myelin stain for counting degenerating neurons in the brain of mice following status epilepticus.
Neurotoxicology 33(4) , 789-95, (2012) The Woelcke method is classically used for myelin staining. Degenerating neurons can be revealed histologically by hemalun and phloxin (H&P) where they appear "eosinophilic". In the first 24 h following soman-induced status epilepticus, we observed that the W... |
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Hematein inhibits atherosclerosis by inhibition of reactive oxygen generation and NF-kappaB-dependent inflammatory mediators in hyperlipidemic mice.
J. Cardiovasc. Pharmacol. 42(2) , 287-95, (2003) Hematein, a natural compound, is a known anti-inflammatory and antiatherogenic agent in the rabbit model. The authors investigated the effects of this compound on atherogenesis and possible mechanisms of the actions in the hyperlipidemic mice. Low-density lip... |