PD 128042
PD 128042 structure
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Common Name | PD 128042 | ||
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| CAS Number | 114289-47-3 | Molecular Weight | 393.56000 | |
| Density | 1.002g/cm3 | Boiling Point | 504.7ºC at 760mmHg | |
| Molecular Formula | C23H39NO4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 259ºC | |
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cPLA2α and EHD1 interact and regulate the vesiculation of cholesterol-rich, GPI-anchored, protein-containing endosomes.
Mol. Biol. Cell 23(10) , 1874-88, (2012) The lipid modifier phospholipase A2 catalyzes the hydrolysis of phospholipids to inverted-cone-shaped lysophospholipids that contribute to membrane curvature and/or tubulation. Conflicting findings exist regarding the function of cytosolic phospholipase A2 (c... |
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Use of acyltransferase inhibitors to block vesicular traffic between the ER and Golgi complex.
Meth. Enzymol. 404 , 115-25, (2005) This article describes the use of acyltransferase inhibitors as probes for studying the potential role of lysophospholipid acyltransferases (LPAT) in intracellular membrane trafficking in the secretory and endocytic pathways. The small molecule inhibitors tha... |
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A unique lysophospholipid acyltransferase (LPAT) antagonist, CI-976, affects secretory and endocytic membrane trafficking pathways.
J. Cell Sci. 118(Pt 14) , 3061-71, (2005) Previous studies have shown that inhibition of a Golgi-complex-associated lysophospholipid acyltransferase (LPAT) activity by the drug CI-976 stimulates Golgi tubule formation and subsequent redistribution of resident Golgi proteins to the endoplasmic reticul... |
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In vitro and in vivo disposition of 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide (CI-976). Identification of a novel five-carbon cleavage metabolite in rats.
Drug Metab. Dispos. 25(1) , 123-30, (1997) The metabolism of CI-976, a potent inhibitor of liver and intestinal acyl coenzyme A:cholesterol acyltransferase, was investigated in isolated rat hepatocytes and Wistar rats after oral administration. The major metabolite observed both in vitro and in vivo w... |
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The lysophospholipid acyltransferase antagonist CI-976 inhibits a late step in COPII vesicle budding.
Traffic 9(5) , 786-97, (2008) The mechanism of coat protein (COP)II vesicle fission from the endoplasmic reticulum (ER) remains unclear. Lysophospholipid acyltransferases (LPATs) catalyze the conversion of various lysophospholipids to phospholipids, a process that can promote spontaneous ... |
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Iron loaded ferritin secretion and inhibition by CI-976 inAedes aegyptilarval cells
Comp. Biochem. Physiol. B Biochem. Mol. Biol. 152(4) , 352-63, (2009) Ferritin is a multimer of 24 subunits of heavy and light chains. In mammals, iron taken into cells is stored in ferritin or incorporated into iron-containing proteins. Very little ferritin is found circulating in mammalian serum; most is retained in the cytop... |
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Acyl-coenzyme A:cholesterol-acyltransferase (ACAT) inhibitors modulate monocyte adhesion to aortic endothelial cells.
Atherosclerosis 112(1) , 7-17, (1995) Increased monocyte adhesion to aortic endothelium is observed in the pathogenesis of atherosclerosis. The role of endothelial acyl-coenzyme A:cholesterol-acyltransferase (ACAT) in the regulation of monocyte adhesion is not known. To examine the potential role... |
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Characterization of a novel CI-976-sensitive lysophospholipid acyltransferase that is associated with the Golgi complex.
Biochem. Biophys. Res. Commun. 313(3) , 681-6, (2004) Recent studies have identified a novel lysophospholipid acyltransferase (LPAT) that is associated with the Golgi complex and that is sensitive to the previously characterized acyl-CoA cholesterol acyltransferase inhibitor, 2,2-methyl-N-(2,4,6-trimethoxyphenyl... |
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Glibenclamide acts as an inhibitor of acyl-CoA:cholesterol acyltransferase enzyme.
Biochem. Biophys. Res. Commun. 277(2) , 417-22, (2000) Sulfonylureas are used in the treatment of non-insulin-dependent diabetes mellitus. Little is known, however, about their effects on cholesterol metabolism. We tested in the present study the effects of glibenclamide (GB) on cholesterol esterification (CE) in... |
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Biochemical evidence for oligomerization of rat adrenal acyl-coenzyme A:cholesterol acyltransferase.
Biochem. Biophys. Res. Commun. 244(2) , 347-52, (1998) Acyl-coenzyme A:cholesterol acyltransferase (ACAT) in rat adrenal was compared with that in rat liver. Immunoblot analyses of the microsomal fractions from adrenal with an anti-human ACAT antibody detected a 45 kDa protein. Upon pretreatment of these microsom... |