CGP 52432
CGP 52432 structure
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Common Name | CGP 52432 | ||
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| CAS Number | 139667-74-6 | Molecular Weight | 384.23500 | |
| Density | 1.258g/cm3 | Boiling Point | 544.4ºC at 760mmHg | |
| Molecular Formula | C15H24Cl2NO4P | Melting Point | N/A | |
| MSDS | USA | Flash Point | 283.1ºC | |
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Correlated changes in NMDA receptor phosphorylation, functional activity, and sedation by chronic ethanol consumption.
J. Neurochem. 115(5) , 1112-22, (2010) Alcohol abuse leads to tolerance, dependence, and memory impairments that involve excitatory glutamatergic NMDA synaptic transmission. The NMDA receptor (NMDAR) is known to undergo activity-dependent adaptive functional changes. Since we observed that acute e... |
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Presynaptic mGlu7 receptors control GABA release in mouse hippocampus.
Neuropharmacology 66 , 215-24, (2013) The functional role of presynaptic release-regulating metabotropic glutamate type 7 (mGlu7) receptors in hippocampal GABAergic terminals was investigated. Mouse hippocampal synaptosomes were preloaded with [(3)H]D-γ-aminobutyric acid ([(3)H]GABA) and then exp... |
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Hippocampal Pyramidal Neurons Comprise Two Distinct Cell Types that Are Countermodulated by Metabotropic Receptors
Neuron 76(4) , 776-89, (2012) Relating the function of neuronal cell types to information processing and behavior is a central goal of neuroscience. In the hippocampus, pyramidal cells in CA1 and the subiculum process sensory and motor cues to form a cognitive map encoding spatial, contex... |
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GABA(B) presynaptic receptors modulate glycine exocytosis from mouse spinal cord and hippocampus glycinergic nerve endings.
Pharmacol. Res. 59(3) , 154-9, (2009) Glycine release and modulation of glycine exocytosis by presynaptic receptors have been rarely studied. We here investigate on the existence and the pharmacological profile of GABA(B) receptors regulating glycine release in mouse spinal cord and hippocampus. ... |
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Activation of GABA-B receptors induced by systemic amphetamine abolishes dopamine release in the rat lateral septum.
J. Neurochem. 114(6) , 1678-86, (2010) The lateral septum is a brain nucleus involved in various mental disorders such as anxiety and drug addiction. In the present study, we investigated whether systemic amphetamine, known to release dopamine (DA) in nucleus accumbens, will also release DA in lat... |
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Alteration of GABAergic neurotransmission by pulsed infrared laser stimulation.
J. Neurosci. Methods 192(1) , 110-4, (2010) Transient electrical impulses are conventionally used to elicit physiological responses in excitable tissues. While electrical stimulation has many advantages, it requires an electrode-tissue interface, exhibits relatively low spatial selectivity and always p... |
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Renoprotective effects of gamma-aminobutyric acid on ischemia/reperfusion-induced renal injury in rats.
Eur. J. Pharmacol. 623(1-3) , 113-8, (2009) Enhanced renal sympathetic nerve activity during ischemic period and the renal venous norepinephrine overflow after reperfusion play important roles in the development of ischemic acute kidney injury. We investigated the effect of gamma-aminobutyric acid (GAB... |
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Blockade of GABA(B) receptors facilitates evoked neurotransmitter release at spinal dorsal horn synapse.
Neuroscience 193 , 411-20, (2011) Metabotropic GABA type B (GABA(B)) receptors are abundantly expressed in the rat spinal dorsal horn. Activation of GABA(B) receptors by exogenous agonists inhibits synaptic transmission, which is believed to underlie the GABA(B) receptor-mediated analgesia. H... |
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GABA(B) restrains release from singly-evoked GABA terminals.
Neuroscience 193 , 54-62, (2011) Neurotransmitter release regulation is highly heterogeneous across the brain. The fundamental units of release, individual boutons, are difficult to access and poorly understood. Here we directly activated single boutons on mechanically isolated nucleus tract... |
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[The role of GABAA and GABAB receptors in formation of evoked potentials in the barrel cortex of rats].
Zh. Vyssh. Nerv. Deiat. Im. I P Pavlova 62(3) , 372-82, (2012) By means of local microapplication of GABA, picrotoxin and CGP 52432, different roles of GABAA and GABAB receptors in the geneses of primary and secondary components of evoked potentials in the somatosensory barrel cortex of rats were shown. The authors concl... |