AC-7954
AC-7954 structure
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Common Name | AC-7954 | ||
|---|---|---|---|---|
| CAS Number | 477313-09-0 | Molecular Weight | 366.28200 | |
| Density | N/A | Boiling Point | 462.8ºC at 760 mmHg | |
| Molecular Formula | C19H21Cl2NO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 233.7ºC | |
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Unraveling the active conformation of urotensin II.
J. Med. Chem. 47 , 1652-61, (2004) Urotensin II (U-II) is a disulfide-bridged undecapeptide recently identified as the ligand of an orphan G-protein-coupled receptor. Human U-II (H-Glu-Thr-Pro-Asp-cyclo[Cys-Phe-Trp-Lys-Tyr-Cys]-Val-OH) has been described as the most potent vasoconstrictor comp... |
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Discovery of the first nonpeptide agonist of the GPR14/urotensin-II receptor: 3-(4-chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954).
J. Med. Chem. 45 , 4950-4953, (2002) A functional cell-based screen identified 3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one hydrochloride (AC-7954, 1) as a nonpeptidic agonist of the urotensin-II receptor. Racemic 1 had an EC50 of 300 nM at the human UII receptor and was highly ... |
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