C2 Ceramide
C2 Ceramide structure
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Common Name | C2 Ceramide | ||
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| CAS Number | 3102-57-6 | Molecular Weight | 341.529 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 532.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H39NO3 | Melting Point | 93-96ºC | |
| MSDS | Chinese USA | Flash Point | 275.8±30.1 °C | |
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Induction of apoptosis in prostate cancer cells by the novel ceramidase inhibitor ceranib-2.
In Vitro Cell. Dev. Biol. Anim. 51 , 1056-63, (2015) Ceramidases are key enzymes that decrease ceramide levels in cells. A reduction in ceramide concentration impairs ceramide signalling, and results in apoptosis resistance in cancer cells. This study investigates the potential for ceranib-2, a novel ceramidase... |
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Sphingolipids are required for efficient triacylglycerol loss in conjugated linoleic Acid treated adipocytes.
PLoS ONE 10(4) , e0119005, (2015) Conjugated linoleic acid (CLA) reduces adiposity in human and mouse adipocytes. This outcome is achieved through a variety of biological responses including increased energy expenditure and fatty acid oxidation, increased inflammation, repression of fatty aci... |
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C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts.
Endocrinology 147 , 4363-73, (2006) The stress kinase c-jun N-terminal kinase (JNK) was recently shown to be involved in the pathophysiology of major inflammatory conditions, including Alzheimer's disease, stroke, obesity, and type II diabetes. However, the role of JNK in regulating inflammator... |
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Ceramide-induced impairment of endothelial function is prevented by CuZn superoxide dismutase overexpression.
Arterioscler. Thromb. Vasc. Biol. 25 , 90-5, (2005) Ceramide is an important intracellular second messenger that may also increase superoxide. The goal of this study was to determine whether overexpression of CuZn superoxide dismutase (SOD) protects against ceramide-induced increases in vascular superoxide and... |
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Sphingomyelinase dependent apoptosis following treatment of pancreatic beta-cells with amyloid peptides Abeta(1-42) or IAPP.
Apoptosis 14 , 878-89, (2009) Amyloid peptides interfere with survival of pancreatic beta-cells. In some cells apoptosis is paralleled by ceramide-dependent alterations of ion channel activity. The purpose of the present study was to elucidate the dependence of amyloid peptides Abeta(1-42... |