Fostriecin
Fostriecin structure
|
Common Name | Fostriecin | ||
|---|---|---|---|---|
| CAS Number | 87860-39-7 | Molecular Weight | 452.36800 | |
| Density | N/A | Boiling Point | 737.9ºC at 760 mmHg | |
| Molecular Formula | C19H26NaO9P | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 400.1ºC | |
|
Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae.
J. Neurosci. 31 , 5512-25, (2011) An imbalance in dopamine-mediated neurotransmission is a hallmark physiological feature of neuropsychiatric disorders, such as schizophrenia. Recent evidence demonstrates that dopamine D(2) receptors, which are the main target of antipsychotics, modulate the ... |
|
|
Fostriecin-mediated G2-M-phase growth arrest correlates with abnormal centrosome replication, the formation of aberrant mitotic spindles, and the inhibition of serine/threonine protein phosphatase activity.
Cancer Res. 58 , 3611-3619, (1998) Fostriecin, a structurally unique phosphate ester, is presently under evaluation in clinical trials to determine its potential use as an antitumor drug in humans. Fostriecin has been reported as having inhibitory activity against DNA topoisomerase type II and... |
|
|
Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A.
FEBS Lett. 416 , 230, (1997) Fostriecin, an antitumor antibiotic produced by Streptomyces pulveraceus, is a strong inhibitor of type 2A (PP2A; IC50 3.2 nM) and a weak inhibitor of type 1 (PP1; IC50 131 microM) serine/threonine protein phosphatases. Fostriecin has no apparent effect on th... |
|
|
Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters.
FEBS Lett. 431 , 357-361, (1998) Protein phosphatase 4 (PP4) is a protein serine/threonine phosphatase that predominantly localises to centrosomes and plays a role in microtubule organisation at centrosomes. Here, PP4 catalytic subunit has been purified from porcine testis to near homogeneit... |
|
|
Novel antitumor agents CI-920, PD 113,270 and PD 113,271. II. Isolation and characterization.
J. Antibiot. 36 , 160-1605, (1983) A complex of structurally related compounds that exhibit in vivo antileukemic activity was isolated from fermentation broths of a new streptomycete. The components of this complex are water soluble phosphate esters containing a conjugated triene system. The i... |
|
|
Novel antitumor agents CI-920, PD 113,270 and PD 113,271. I. Taxonomy, fermentation and biological properties.
J. Antibiot. 36 , 1595-1600, (1983) CI-920 (PD 110,161) and two analogues (PD 113,270 and PD 113,271) are novel antitumor compounds produced by a new actinomycete characterized as Streptomyces pulveraceus subsp. fostreus ATCC 31906. The antitumor compounds are predominantly produced during the ... |