butyl 9H-pyrido[3,4-b]indole-3-carboxylate
![butyl 9H-pyrido[3,4-b]indole-3-carboxylate Structure](https://image.chemsrc.com/caspic/306/84454-35-3.png)
butyl 9H-pyrido[3,4-b]indole-3-carboxylate structure
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Common Name | butyl 9H-pyrido[3,4-b]indole-3-carboxylate | ||
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| CAS Number | 84454-35-3 | Molecular Weight | 268.31000 | |
| Density | 1.238g/cm3 | Boiling Point | 483.9ºC at 760 mmHg | |
| Molecular Formula | C16H16N2O2 | Melting Point | 210-211ºC | |
| MSDS | Chinese USA | Flash Point | 246.5ºC | |
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Hormonal factors from the mammalian pineal gland interfere with cell development in Hydra.
Int. J. Dev. Biol. 42(6) , 821-4, (1998) A partially purified, melatonin-free low-molecular-weight extract from the ovine pineal gland with antitumor activity (YC05R), interferes with terminal differentiation in the interstitial cell line of Hydra. Nematoblasts developed into defective nematocytes t... |
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Isolation and identification in bovine cerebral cortex of n-butyl beta-carboline-3-carboxylate, a potent benzodiazepine binding inhibitor.
Proc. Natl. Acad. Sci. U. S. A. 83(13) , 4952-6, (1986) A substance having benzodiazepine-binding inhibitory activity has been extracted from 18 kg of gray matter of bovine cerebral cortex and purified to homogeneity. This substance inhibits competitively [3H]flunitrazepam and ethyl beta-[3H]carboline-3-carboxylat... |
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Proconvulsant and 'anxiogenic' effects of n-butyl beta carboline-3-carboxylate, an endogenous benzodiazepine binding inhibitor from brain.
Pharmacol. Biochem. Behav. 30(2) , 331-6, (1988) The discovery of n-butyl beta carboline-3-carboxylate (beta CCB) as an endogenous substance of brain capable of interacting with the central benzodiazepine receptor, and the fact that this beta carboline increases in the cerebral cortex of rats undergoing acu... |
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Beta-carbolines induce apoptosis in cultured cerebellar granule neurons via the mitochondrial pathway.
Neuropharmacology 48(1) , 105-17, (2005) N-butyl-beta-carboline-3-carboxylate (betaCCB) is, together with 2-methyl-norharmanium and 2,9-dimethylnorharmanium ions, an endogenously occurring beta-carboline. Due to their structural similarities with the synthetic neurotoxin 1-methyl-4-phenyl-1,2,3,6-te... |
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n-[3H]butyl-beta-carboline-3-carboxylate, a putative endogenous ligand, binds preferentially to subtype 1 of central benzodiazepine receptors.
J. Neurochem. 52(3) , 665-70, (1989) Synthetic n-butyl beta-carboline-3-carboxylate, an endogenous central benzodiazepine receptor inhibitor found in brain, was tritium-labeled from the butenyl ester. Binding of this [3H]beta-carboline was concentrated particularly in the synaptosomal membrane f... |
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Determination of n-butyl-beta-carboline-3-carboxylate in aqueous brain extracts.
J. Chromatogr. A. 431(1) , 192-6, (1988)
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Astroglia-released factor shows similar effects as benzodiazepine inverse agonists.
J. Neurosci. Res. 39(4) , 364-76, (1994) Media conditioned by cultured neonatal cerebral cortex microexplants (CCM) or astrocytes (ACM) contain low molecular weight (< 1,000 Da) substance(s) which inhibits the gamma aminobutyric acid (GABA)-induced inward current recorded in cerebellar granule cells... |
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A high-throughput functional assay for characterization of gamma-aminobutyric acid(A) channel modulators using cryopreserved transiently transfected cells.
Assay Drug Dev. Technol. 6(6) , 781-6, (2008) The ionotropic -aminobutyric acid (GABA)A receptors are an important family of drug targets for a variety of neurological and psychiatric disorders. Selective modulation of certain subtypes of the receptor could lead to novel or improved therapies. However, t... |
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Benzodiazepine receptor ligand influences on acquisition: suggestion of an endogenous modulatory mechanism mediated by benzodiazepine receptors.
Behav. Neural Biol 54(1) , 27-41, (1990) In rats, pretraining ip administration of the central benzodiazepine receptor antagonist, flumazenil (5.0 mg/kg), or of the inverse agonist, n-butyl-beta-carboline-3-carboxylate (BCCB) (0.2 or 0.5 mg/kg), facilitated retention of a step-down inhibitory avoida... |