L-Aspartic acid β-(7-amido-4-methylcoumarin)
L-Aspartic acid β-(7-amido-4-methylcoumarin) structure
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Common Name | L-Aspartic acid β-(7-amido-4-methylcoumarin) | ||
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| CAS Number | 133628-73-6 | Molecular Weight | 290.27100 | |
| Density | 1.452g/cm3 | Boiling Point | 610ºC at 760mmHg | |
| Molecular Formula | C14H14N2O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 322.7ºC | |
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Applications of a new fluorimetric enzyme assay for the diagnosis of aspartylglucosaminuria.
J. Inherit. Metab. Dis. 16 , 929-934, (1993) L-Aspartic acid-beta-7-amido-4-methylcoumarin is a sensitive and specific fluorogenic substrate for lysosomal glycoasparaginase (aspartylglucosaminidase). Fibroblasts and leukocytes from 8 patients with aspartylglucosaminuria, showed 1-7% of the mean normal g... |
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Structural basis of aspartylglucosaminuria.
Biochem. Biophys. Res. Commun. 377 , 1168-1172, (2008) To elucidate the basis of aspartylglucosaminuria (AGU) from the viewpoint of enzyme structure, we constructed structural models of mutant aspartylglucosaminidase (AGA) proteins using molecular modeling software, TINKER. We classified the amino acid substituti... |
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Enzymatic diagnosis of aspartylglycosaminuria by fluorometric assay of glycosylasparaginase in serum, plasma, or lymphocytes.
Clin. Chem. 40 , 385-388, (1994) Serum, plasma, and lymphocytes from aspartylglycosaminuria (AGU) patients and carriers and from normal controls were incubated with a fluorescent glycosylasparaginase substrate, L-aspartic acid beta-(7-amido-4-methylcoumarin), and the release of 7-amino-4-met... |
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A fluorometric assay for glycosylasparaginase activity and detection of aspartylglycosaminuria.
Anal. Biochem. 208 , 372-374, (1993) Recent experimental work on the mechanism of action of glycosylasparaginase suggests that the enzyme specifically reacts toward the L-asparagine or L-aspartic acid moiety of its substrates. Based on this, a new sensitive assay for glycosylasparaginase activit... |
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A fluorometric assay for L-asparaginase activity and monitoring of L-asparaginase therapy.
Anal. Biochem. 280 , 42-45, (2000) The antineoplastic enzyme L-asparaginase is commonly used for the induction of remission in acute lymphoblastic leukemia (ALL). There is no simple method available for measuring the activity of this highly toxic drug. We incubated L-asparaginase from Erwinia ... |