Theaflavin
Theaflavin structure
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Common Name | Theaflavin | ||
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| CAS Number | 4670-05-7 | Molecular Weight | 564.49 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 926.2±65.0 °C at 760 mmHg | |
| Molecular Formula | C29H24O12 | Melting Point | 240 °C | |
| MSDS | Chinese USA | Flash Point | 314.3±27.8 °C | |
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Theaflavins, dimeric catechins, inhibit peptide transport across Caco-2 cell monolayers via down-regulation of AMP-activated protein kinase-mediated peptide transporter PEPT1.
Food Chem. 138(4) , 2140-5, (2013) In the small intestine, peptide transporter 1 (PEPT1) plays a role in the transport of di- and tripeptides. In this study, we investigated whether theaflavins (TFs) affect the absorption of small peptides in human intestinal Caco-2 cells, since TFs do not pen... |
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Polyphenols extracted from black tea (Camellia sinensis) residue by hot-compressed water and their inhibitory effect on pancreatic lipase in vitro.
J. Food Sci. 77(12) , H254-61, (2012) Polyphenols, retained in black tea wastes following the commercial production of tea beverages, represent an underutilized resource. The purpose of this study was to investigate the potential use of hot-compressed water (HCW) for the extraction of pancreatic ... |
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Therapeutic attenuation of neuroinflammation and apoptosis by black tea theaflavin in chronic MPTP/probenecid model of Parkinson's disease.
Neurotox. Res. 23(2) , 166-73, (2013) Neuroinflammation and apoptosis in the dopaminergic neurons of substantia nigra play an important role in the pathogenesis of experimental and clinical Parkinson's disease (PD). This study focused on the possible anti-inflammatory and anti-apoptotic effects o... |
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Tea polyphenols enhance cisplatin chemosensitivity in cervical cancer cells via induction of apoptosis.
Life Sci. 93(1) , 7-16, (2013) Constitutive activation of nuclear factor-kappaB (NF-κB) and Akt has been implicated in chemoresistance as well as inhibition of apoptosis to cisplatin (CDDP), therefore, we examined whether (-) epigallocateocatechin-3-gallate (EGCG) or theaflavins (TF) could... |
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Comparative antimutagenic and anticancer activity of three fractions of black tea polyphenols thearubigins.
Nutr. Cancer 63(7) , 1122-32, (2011) Antimutagenic and anticancer effects of black tea polyphenols theaflavins (TF) and thearubigins (TR) have previously been reported. TR is a complex mixture of polyphenols. In this study, our interest was to fractionate TR and to study the antimutagenic and an... |
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Black tea polyphenols induce human leukemic cell cycle arrest by inhibiting Akt signaling: possible involvement of Hsp90, Wnt/β-catenin signaling and FOXO1.
FEBS J. 279(16) , 2876-91, (2012) Tea polyphenols have potent biological activities against human cancer cells. A major causative factor in malignancies is disregulation of cell-cycle kinetics. In this study, we observed that black tea polyphenols, theaflavins (TF) and thearubigins (TR) induc... |
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Theaflavin attenuates ischemia-reperfusion injury in a mouse fatty liver model.
Biochem. Biophys. Res. Commun. 417(1) , 287-93, (2012) The incidence of non-alcoholic fatty liver disease (NAFLD) has been increasing, and there is a shortage of liver donors, which has led to the acceptance of steatotic livers for transplantation. However, steatotic livers are known to experience more severe acu... |
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Protective effect of theaflavins on cadmium-induced testicular toxicity in male rats.
Food Chem. Toxicol. 50(9) , 3243-50, (2012) Male Sprague-Dawley rats were treated with cadmium (Cd) (0.4 mg/kg body weight, s.c., once a day) and three concentrations of theaflavins (50, 100 or 200mg/kg body weight, orally, once a day) for five weeks to evaluate the protective role of theaflavins on Cd... |
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Black tea polyphenols inhibit tumor proteasome activity.
In Vivo 26(2) , 197-202, (2012) Tea is a widely consumed beverage and its constituent polyphenols have been associated with potential health benefits. Although black tea polyphenols have been reported to possess potent anticancer activities, the effect of its polyphenols, theaflavins on the... |
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Vaginal gel formulation based on theaflavin derivatives as a microbicide to prevent HIV sexual transmission.
AIDS Res. Hum. Retroviruses 28(11) , 1498-508, (2012) We previously demonstrated that a commercially available natural product preparation with high content (>90%) of theaflavin derivatives (TFmix) exhibited potent anti-HIV activities. Here we developed a TFmix gel formulation as a topical microbicide candidate.... |