cafestol acetate
cafestol acetate structure
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Common Name | cafestol acetate | ||
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| CAS Number | 81760-48-7 | Molecular Weight | 358.47100 | |
| Density | 1.21g/cm3 | Boiling Point | 474.6ºC at 760mmHg | |
| Molecular Formula | C22H30O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 240.8ºC | |
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Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver.
Food Chem. Toxicol. 46 , 1230-1238, (2008) Coffee drinking appears to reduce cancer risk in liver and colon. Such chemoprevention may be caused by the diterpenes kahweol and cafestol (K/C) contained in unfiltered beverage. In animals, K/C treatment inhibited the mutagenicity/tumorigenicity of several ... |
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Protective effects of kahweol and cafestol against hydrogen peroxide-induced oxidative stress and DNA damage.
Toxicol. Lett. 173 , 80-87, (2007) There is an increasing evidence that oxidative stress is implicated in the processes of inflammation and carcinogenesis. It has been shown that kahweol and cafestol, coffee-specific diterpenes, exhibit chemoprotective effects. This study investigated the effe... |
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Inhibition of the fungal fatty acid synthase type I multienzyme complex.
Proc. Natl. Acad. Sci. U. S. A. 105 , 12803-8, (2008) Fatty acids are among the major building blocks of living cells, making lipid biosynthesis a potent target for compounds with antibiotic or antineoplastic properties. We present the crystal structure of the 2.6-MDa Saccharomyces cerevisiae fatty acid synthase... |
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Cafestol, a coffee-specific diterpene, induces apoptosis in renal carcinoma Caki cells through down-regulation of anti-apoptotic proteins and Akt phosphorylation.
Chem. Biol. Interact. 190 , 102-108, (2011) Cafestol, one of the major compounds in coffee beans, has been reported for its tumor cell growth inhibitory activity and anti-carcinogenic activity, although the mechanism of action is poorly understood. In the present study, we investigated the effect of ca... |
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Coffee and liver diseases.
Fitoterapia 81 , 297-305, (2010) Coffee consumption is worldwide spread with few side effects. Interestingly, coffee intake has been inversely related to the serum enzyme activities gamma-glutamyltransferase, and alanine aminotransferase in studies performed in various countries. In addition... |
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The multifaceted mechanisms for coffee's anti-tumorigenic effect on liver.
Med. Hypotheses 71 , 730-736, (2008) Epidemiological studies have found an inverse association between coffee consumption and the risk of liver cancer. Animal data support such a chemopreventive effect of coffee. Substantial research has been devoted to the identification of coffee components th... |
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Cafestol, a coffee-specific diterpene, is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages.
Biol. Pharm. Bull. 33 , 128-132, (2010) Coffee is a popular beverage worldwide with various nutritional benefits. Diterpene cafestol, one of the major components of coffee, contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatopr... |
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Use of silver nitrate impregnated silica cartridges in the separation of kahweol and cafestol esters by preparative liquid chromatography.
J. Chromatogr. A. 328 , 422-4, (1985)
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