Prostratin
Prostratin structure
|
Common Name | Prostratin | ||
|---|---|---|---|---|
| CAS Number | 60857-08-1 | Molecular Weight | 390.470 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 550.5±50.0 °C at 760 mmHg | |
| Molecular Formula | C22H30O6 | Melting Point | 216-219℃ | |
| MSDS | Chinese USA | Flash Point | 188.7±23.6 °C | |
|
IFI44 suppresses HIV-1 LTR promoter activity and facilitates its latency.
Virology 481 , 142-50, (2015) IFI44 is an interferon-alfa inducible protein, and is associated with infection of several viruses. However, IFI44 elicits minimal antiviral effects on these viruses, and its exact role is still unknown. Here we show that IFI44 inhibits HIV-1 replication in v... |
|
|
Sulfonation pathway inhibitors block reactivation of latent HIV-1.
Virology 471-473 , 1-12, (2014) Long-lived pools of latently infected cells are a significant barrier to the development of a cure for HIV-1 infection. A better understanding of the mechanisms of reactivation from latency is needed to facilitate the development of novel therapies that addre... |
|
|
Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection.
PLoS ONE 4(6) , e6093, (2009) The persistence of transcriptionally silent but replication-competent HIV-1 reservoirs in Highly Active Anti-Retroviral Therapy (HAART)-treated infected individuals, represents a major hurdle to virus eradication. Activation of HIV-1 gene expression in these ... |
|
|
Epigenetic regulation of HIV-1 transcription.
Epigenomics 3(4) , 487-502, (2011) After entry into the target cell and reverse transcription, HIV-1 genes are integrated into the host genome. It is now well established that the viral promoter activity is directly governed by its chromatin environment. Nuc-1, a nucleosome located immediately... |
|
|
The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents.
Cancer Lett. 356(2 Pt B) , 686-96, (2015) As acute myeloid leukemia (AML) cells are characterized by uncontrolled self-renewal and impaired cellular differentiation, induction of terminal differentiation of leukemia cells by differentiating agents has been proposed as an attractive therapeutic strate... |
|
|
Reactivation of latent HIV-1 by inhibition of BRD4.
Cell Rep. 2(4) , 807-16, (2012) HIV-1 depends on many host factors for propagation. Other host factors, however, antagonize HIV-1 and may have profound effects on viral activation. Curing HIV-1 requires the reduction of latent viral reservoirs that remain in the face of antiretroviral thera... |
|
|
Prostratin induces HIV activation and downregulates HIV receptors in peripheral blood lymphocytes.
Antivir. Ther. (Lond.) 9(4) , 545-54, (2004) Induction of HIV expression through lymphocyte activation has been proposed as a strategy to purge latent reservoirs. Prostratin is a non-tumourogenic phorbol ester that delays HIV replication in vitro, but paradoxically activates HIV expression in latently i... |
|
|
Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue.
J. Virol. 78(19) , 10507-15, (2004) To design strategies to purge latent reservoirs of human immunodeficiency virus type 1 (HIV-1), we investigated mechanisms by which a non-tumor-promoting phorbol ester, prostratin, inhibits infection of CD4(+) T lymphocytes and at the same time reactivates vi... |
|
|
Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells.
Retrovirology 3 , 66, (2006) The latent reservoir of human immunodeficiency virus type 1 (HIV-1) in resting CD4+ T cells is a major obstacle to the clearance of infection by highly active antiretroviral therapy (HAART). Recent studies have focused on searches for adjuvant therapies to ac... |
|
|
Prostratin and bortezomib are novel inducers of latent Kaposi's sarcoma-associated herpesvirus.
Antivir. Ther. (Lond.) 10(6) , 745-51, (2005) Kaposi's sarcoma-associated herpesvirus (KSHV) establishes latent infections in lymphocytes and endothelial cells, and latent infection is closely linked to tumorigenesis. As few viral markers are expressed during latency, compounds that can safely and effici... |