Nabumetone
Nabumetone structure
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Common Name | Nabumetone | ||
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| CAS Number | 42924-53-8 | Molecular Weight | 228.286 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 371.1±17.0 °C at 760 mmHg | |
| Molecular Formula | C15H16O2 | Melting Point | 80-81ºC | |
| MSDS | Chinese USA | Flash Point | 165.4±14.5 °C | |
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Exploration of alternate catalytic mechanisms and optimization strategies for retroaldolase design.
J. Mol. Biol. 426(1) , 256-71, (2014) Designed retroaldolases have utilized a nucleophilic lysine to promote carbon-carbon bond cleavage of β-hydroxy-ketones via a covalent Schiff base intermediate. Previous computational designs have incorporated a water molecule to facilitate formation and brea... |
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Hypersensitivity to nabumetone: cross reactivity with naproxen.
Ann. Allergy Asthma Immunol. 111(1) , 74-5, (2013)
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Effects of nabumetone and dipyrone on experimentally induced gastric ulcers in rats.
Inflammation 36(2) , 476-81, (2013) Nabumetone and dipyrone are non-acidic, nonsteroidal anti-inflammatory drugs. Both of them are known to have weak inhibitory effects of cyclooxygenases. Gastric side effects represent the most common adverse drug effects of the widely used nonsteroidal anti-i... |
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A review of analytical techniques for determination of oxicams, nimesulide and nabumetone.
Talanta 77(3) , 925-42, (2009) Non-steroidal anti-inflammatory drugs (NSAIDs) are the group most often used in human health care, since they are available without prescription for treatment of fever and minor pain. The present review submitted the use of various analytical techniques for t... |
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[Rationale for using nabumetone and clinical experience].
Drugs 59 Spec No 1 , 35-41, (2000) Nabumetone's position as one of the most commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) in the world today is based upon over a decade of clinical experience. The popularity of this drug lies in both its unique pharmacokinetic profile and special... |
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A diclofenac suppository-nabumetone combination therapy for arthritic pain relief and a monitoring method for the diclofenac binding capacity of HSA site II in rheumatoid arthritis.
Biopharm. Drug Dispos. 34(2) , 125-36, (2013) Diclofenac suppository, a non-steroidal anti-inflammatory drug (NSAID), is used widely in rheumatoid arthritis (RA) patients with severe arthritic pain. As the binding percentage of diclofenac to serum proteins is high, its free (unbound) concentration after ... |
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Nabumetone: a clinical appraisal.
Semin. Arthritis Rheum. 23(5) , 341-6, (1994) Nonsteroidal antiinflammatory drugs (NSAIDs) have long been used as therapy for arthritis patients. However, in some patients these drugs can cause gastrointestinal hemorrhage, perforation, or ulcer through direct topical effects, enterohepatic recirculation,... |
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Effect of a nonprotein bioactive agent on the reduction of cyclooxygenase-2 and tumor necrosis factor-alpha in human intervertebral disc cells in vitro.
J. Neurosurg. Spine 9(5) , 411-8, (2008) Neurotropin is a nonprotein extract from the inflamed skin of rabbits inoculated with vaccinia virus. In the present study the authors sought to clarify the focal antiinflammatory effects of Neurotropin in intervertebral disc cells, and these effects were com... |
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In vitro characterization of the cytochrome P450 isoforms involved in the metabolism of 6-methoxy-2-napthylacetic acid, an active metabolite of the prodrug nabumetone.
Biol. Pharm. Bull. 34(5) , 734-9, (2011) The cytochrome P450 (CYP) isoforms that catalyze the oxidation metabolism of 6-methoxy-2-napthylacetic acid (6-MNA), an active metabolite of nabumetone, were studied in rats and humans. Using an extractive reversed-phase HPLC assay with fluorescence detection... |
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High-throughput LC-MS/MS assay for 6-methoxy-2-naphthylacetic acid, an active metabolite of nabumetone in human plasma and its application to bioequivalence study.
Biomed. Chromatogr. 22(11) , 1213-24, (2008) A simple, precise and accurate assay for the determination of 6-methoxy-2-naphthylacetic acid (6-MNA), an active metabolite of nabumetone in human plasma, was developed and validated using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The analyte... |