Acarbose
Acarbose structure
|
Common Name | Acarbose | ||
|---|---|---|---|---|
| CAS Number | 56180-94-0 | Molecular Weight | 645.605 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 971.6±65.0 °C at 760 mmHg | |
| Molecular Formula | C25H43NO18 | Melting Point | 165-170ºC | |
| MSDS | Chinese USA | Flash Point | 541.4±34.3 °C | |
|
Hypoglycemic, antihyperglycemic, and antioxidant effects of the edible plant Anoda cristata.
J. Ethnopharmacol. 161 , 36-45, (2015) Some studies refer that the entire plant of Anoda cristata is consumed as food and medicine; in particular for treating diabetes, inflammation, fever, cough, and wounds. The aim of this study was to establish the preclinical efficacy of Anoda cristata as hypo... |
|
|
Antitumor effects and immune regulation activities of a purified polysaccharide extracted from Juglan regia.
Int. J. Biol. Macromol. 72 , 771-5, (2014) A water-soluble polysaccharide, named as JRP1, was extracted and fractioned from the epicarp of immature fruit of Juglans mandshurica Maxim. The determination of the monosaccharide composition in JRP1 with gas chromatography (GC) showed that JRP1 was composed... |
|
|
Hypolipidemic and hypoglycemic effects of Centella asiatica (L.) extract in vitro and in vivo.
Indian J. Exp. Biol. 52(10) , 965-71, (2014) In vitro study revealed that pancreatic lipase inhibitory activity of C. asiatica extract was significantly higher than rutin but lower than orlistat, an anti-obesity drug. alpha-Amylase inhibitory activities of C. asiatica extract and rutin were significantl... |
|
|
A case of slowly progressive type 1 diabetes with insulin independence maintained for 10 years with α-glucosidase inhibitor monotherapy.
Intern. Med. 51(24) , 3391-4, (2012) Slowly Progressive Type 1 Diabetes (SPT1D) is characterized by the absence of insulin dependence at the onset of diabetes and persistent detection of islet cell autoantibodies. These patients with high titers of glutamic acid decarboxylase autoantibodies (GAD... |
|
|
A column-switching HPLC-MS/MS method for mucopolysaccharidosis type I analysis in a multiplex assay for the simultaneous newborn screening of six lysosomal storage disorders.
Biomed. Chromatogr. 28(8) , 1131-9, (2014) Lysosomal storage disorders comprise a group of rare genetic diseases in which a deficit of specific hydrolases leads to the storage of undegraded substrates in lysosomes. Impaired enzyme activities can be assessed by MS/MS quantification of the reaction prod... |
|
|
Antithrombotic and antidiabetic flavonoid glycosides from the grains of Sorghum bicolor (L.) Moench var. hwanggeumchal.
Arch. Pharm. Res. 37(11) , 1394-402, (2014) A phytochemical study of the grains of S. bicolor, resulting in the isolation of twelve flavonoid glycosides 1-12. Their chemical structures were elucidated on the basis of spectroscopic (1D and 2D NMR) and MS data analyses. All compounds were tested on throm... |
|
|
Evaluation of hypoglycemic effects of polyphenols and extracts from Penthorum chinense.
J. Ethnopharmacol. 163 , 256-63, (2015) Penthorum chinense Pursh has a long history of use as a health food and folk medicine to alleviate "heat"-associated disorders, promote circulation and diuresis, and to treat liver problems, and to protect the spleen. In this study we provide experimental evi... |
|
|
Antidiabetic property of Symplocos cochinchinensis is mediated by inhibition of alpha glucosidase and enhanced insulin sensitivity.
PLoS ONE 9(9) , e105829, (2014) The study is designed to find out the biochemical basis of antidiabetic property of Symplocos cochinchinensis (SC), the main ingredient of 'Nisakathakadi' an Ayurvedic decoction for diabetes. Since diabetes is a multifactorial disease, ethanolic extract of th... |
|
|
Lactobacillus strains isolated from infant faeces possess potent inhibitory activity against intestinal alpha- and beta-glucosidases suggesting anti-diabetic potential.
Eur. J. Nutr. 53(7) , 1465-74, (2014) Inhibitors of intestinal alpha-glucosidases are used therapeutically to treat type 2 diabetes mellitus. Bacteria such as Actinoplanes sp. naturally produce potent alpha-glucosidase inhibitor compounds, including the most widely available drug acarbose. It is ... |
|
|
Novel benzoxazine-based aglycones block glucose uptake in vivo by inhibiting glycosidases.
PLoS ONE 9(7) , e102759, (2014) Glycoside hydrolases catalyze the selective hydrolysis of glycosidic bonds in oligosaccharides, polysaccharides, and their conjugates. β-glucosidases occur in all domains of living organisms and constitute a major group among glycoside hydrolases. On the othe... |