Adenosine-2'-monophosphate
Adenosine-2'-monophosphate structure
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Common Name | Adenosine-2'-monophosphate | ||
|---|---|---|---|---|
| CAS Number | 130-49-4 | Molecular Weight | 347.221 | |
| Density | 2.3±0.1 g/cm3 | Boiling Point | 815.5±75.0 °C at 760 mmHg | |
| Molecular Formula | C10H14N5O7P | Melting Point | N/A | |
| MSDS | USA | Flash Point | 447.0±37.1 °C | |
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The RimL transacetylase provides resistance to translation inhibitor microcin C.
J. Bacteriol. 196(19) , 3377-85, (2014) Peptide-nucleotide antibiotic microcin C (McC) is produced by some Escherichia coli strains. Inside a sensitive cell, McC is processed, releasing a nonhydrolyzable analog of aspartyl-adenylate, which inhibits aspartyl-tRNA synthetase. The product of mccE, a g... |
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Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.
Nature 506(7486) , 111-5, (2014) Faithful maintenance and propagation of eukaryotic genomes is ensured by three-step DNA ligation reactions used by ATP-dependent DNA ligases. Paradoxically, when DNA ligases encounter nicked DNA structures with abnormal DNA termini, DNA ligase catalytic activ... |
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Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation.
Biochem. J. 465(2) , 227-38, (2015) Cells respond to external stress conditions by controlling gene expression, a process which occurs rapidly via post-transcriptional regulation at the level of protein synthesis. Global control of translation is mediated by modification of translation factors ... |
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A large solvent isotope effect on protein association thermodynamics.
Biochemistry 52(38) , 6595-600, (2013) Solvent reorganization can contribute significantly to the energetics of protein-protein interactions. However, our knowledge of the magnitude of the energetic contribution is limited, in part, by a dearth of quantitative experimental measurements. The biotin... |
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Site-directed mutagenesis maps interactions that enhance cognate and limit promiscuous catalysis by an alkaline phosphatase superfamily phosphodiesterase.
Biochemistry 52(51) , 9167-76, (2013) Catalytic promiscuity, an evolutionary concept, also provides a powerful tool for gaining mechanistic insights into enzymatic reactions. Members of the alkaline phosphatase (AP) superfamily are highly amenable to such investigation, with several members havin... |
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Kindlin-2 regulates hemostasis by controlling endothelial cell-surface expression of ADP/AMP catabolic enzymes via a clathrin-dependent mechanism.
Blood 122(14) , 2491-9, (2013) Kindlin-2, a widely distributed cytoskeletal protein, has been implicated in integrin activation, and its absence is embryonically lethal in mice. In the present study, we tested whether hemostasis might be perturbed in kindlin-2(+/-) mice. Bleeding time and ... |
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Effects of cigarette smoke on methacholine- and AMP-induced air trapping in asthmatics.
J. Asthma 52(1) , 26-33, (2015) Abstract Objective: No information is available on the effect of cigarette smoke on bronchoconstrictor-induced air trapping in asthma. The aim of this study was to evaluate the additional influence of smoking on methacholine- and adenosine 5'-monophosphate (A... |
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A cell-autonomous molecular cascade initiated by AMP-activated protein kinase represses steroidogenesis.
Mol. Cell. Biol. 34(23) , 4257-71, (2014) Steroid hormones regulate essential physiological processes, and inadequate levels are associated with various pathological conditions. In testosterone-producing Leydig cells, steroidogenesis is strongly stimulated by luteinizing hormone (LH) via its receptor... |
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Identification and characterisation of the phenolics of Ilex glabra L. Gray (Aquifoliaceae) leaves by liquid chromatography tandem mass spectrometry.
Plant Physiol. Biochem. 70 , 504-11, (2013) The phenolics of the leaves of Ilex glabra L. Gray (Aquifoliaceae) were investigated qualitatively by LC-MS(n). Thirty-two phenolics were detected and characterised on the basis of their unique fragmentation pattern in the negative ion mode tandem MS spectra.... |
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Mechanism and regulation of mycobactin fatty acyl-AMP ligase FadD33.
J. Biol. Chem. 288(39) , 28116-25, (2013) Mycobacterial siderophores are critical components for bacterial virulence in the host. Pathogenic mycobacteria synthesize iron chelating siderophores named mycobactin and carboxymycobactin to extract intracellular macrophage iron. The two siderophores differ... |