DL-Tryptophan

DL-Tryptophan Structure
DL-Tryptophan structure
Common Name DL-Tryptophan
CAS Number 54-12-6 Molecular Weight 204.225
Density 1.4±0.1 g/cm3 Boiling Point 447.9±35.0 °C at 760 mmHg
Molecular Formula C11H12N2O2 Melting Point 289-290ºC
MSDS Chinese USA Flash Point 224.7±25.9 °C

Improved characterization of EV preparations based on protein to lipid ratio and lipid properties.

PLoS ONE 10(3) , e0121184, (2015)

In recent years the study of extracellular vesicles has gathered much scientific and clinical interest. As the field is expanding, it is becoming clear that better methods for characterization and quantification of extracellular vesicles as well as better sta...

Regulation and Quality Control of Adiponectin Assembly by Endoplasmic Reticulum Chaperone ERp44.

J. Biol. Chem. 290 , 18111-23, (2015)

Adiponectin, a collagenous hormone secreted abundantly from adipocytes, possesses potent antidiabetic and anti-inflammatory properties. Mediated by the conserved Cys(39) located in the variable region of the N terminus, the trimeric (low molecular weight (LMW...

The Analysis of Pendolino (peo) Mutants Reveals Differences in the Fusigenic Potential among Drosophila Telomeres.

PLoS Genet. 11 , e1005260, (2015)

Drosophila telomeres are sequence-independent structures that are maintained by transposition to chromosome ends of three specialized retroelements (HeT-A, TART and TAHRE; collectively designated as HTT) rather than telomerase activity. Fly telomeres are prot...

Functional constituents of a local serotonergic system, intrinsic to the human coronary artery smooth muscle cells.

Mol. Biol. Rep. 42 , 1295-307, (2015)

Human coronary artery smooth muscle cells (HCASMCs) play an important role in the pathogenesis of coronary atherosclerosis and coronary artery diseases (CAD). Serotonin is a mediator known to produce vascular smooth muscle cell mitogenesis and contribute to c...

A DNA-scaffolded silver nanocluster/Cu²⁺ ensemble as a turn-on fluorescent probe for histidine.

Analyst 139(12) , 3122-6, (2014)

A new type of rapid, sensitive, and selective fluorescence turn-on assay was developed for detection of histidine using a DNA-scaffolded silver nanocluster/Cu(2+) ensemble (DNA-AgNC/Cu(2+)). Cu(2+) was first bound to nucleic acids of the DNA-AgNCs forming a D...

Behavioral Deficits Are Accompanied by Immunological and Neurochemical Changes in a Mouse Model for Neuropsychiatric Lupus (NP-SLE).

Int. J. Mol. Sci. 16 , 15150-71, (2015)

Neuropsychiatric symptoms of systemic lupus erythematosus (NP-SLE) have been understudied compared to end-organ failure and peripheral pathology. Neuropsychiatric symptoms, particularly affective and cognitive indications, may be among the earliest manifestat...

Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART.

J. Neurovirol. 21 , 449-63, (2015)

Activation of the kynurenine pathway (KP) of tryptophan catabolism likely contributes to HIV-associated neurological disorders. However, KP activation in brain tissue during HIV infection has been understudied, and the effect of combination antiretroviral the...

Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV-seropositive individuals with cognitive impairment.

J. Neurovirol. 20(6) , 620-6, (2014)

Elevated cerebrospinal fluid (CSF) levels of markers of oxidative stress, neuronal injury, and inflammation and decreased neurotransmitter levels have been reported in HIV-associated neurocognitive disorders (HAND). Minocycline may have a neuroprotective effe...

Relative quantification of amine-containing metabolites using isobaric N,N-dimethyl leucine (DiLeu) reagents via LC-ESI-MS/MS and CE-ESI-MS/MS.

Analyst 140(2) , 467-75, (2014)

Tandem mass spectrometry (MS/MS)-based relative quantification by isobaric labeling is a useful technique to compare different metabolic expression levels in biological systems. For the first time, we have labeled primary and secondary amine-containing small ...

Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia--significance for activation of the kynurenine pathway.

J. Psychiatry Neurosci. 40(2) , 126-33, (2015)

Accumulating evidence indicates that schizophrenia is associated with brain immune activation. While a number of reports suggest increased cytokine levels in patients with schizophrenia, many of these studies have been limited by their focus on peripheral cyt...