Sodium Bis(4-nitrophenyl) Phosphate
Sodium Bis(4-nitrophenyl) Phosphate structure
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Common Name | Sodium Bis(4-nitrophenyl) Phosphate | ||
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| CAS Number | 4043-96-3 | Molecular Weight | 362.16400 | |
| Density | N/A | Boiling Point | 545.7ºC at 760 mmHg | |
| Molecular Formula | C12H8N2NaO8P | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 283.8ºC | |
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Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation.
J. Pharmacol. Exp. Ther. 344(3) , 665-72, (2013) Clopidogrel pharmacotherapy is associated with substantial interindividual variability in clinical response, which can translate into an increased risk of adverse outcomes. Clopidogrel, a recognized substrate of hepatic carboxylesterase 1 (CES1), undergoes ex... |
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Hydrolysis of bis(p-nitrophenyl)phosphate by tetravalent metal complexes with Klaui's oxygen tripodal ligand.
Inorg. Chem. 49(5) , 2232-8, (2010) The treatment of HfCl(4) with NaL(OEt) (L(OEt)(-) = [(eta(5)-C(5)H(5))Co{P(O)(OEt)(2)}(3)](-)) in nitric acid afforded L(OEt)Hf(NO(3))(3) (1). Hydrolysis of 1 in acetone/water (4:1, v/v) yielded the hydroxy-bridged dimer [(L(OEt))(2)Hf(2)(H(2)O)(4)(mu-OH)(2)]... |
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Mechanistic role of each metal ion in Streptomyces dinuclear aminopeptidase: PEPTIDE hydrolysis and 7x10(10)-fold rate enhancement of phosphodiester hydrolysis.
J. Inorg. Biochem. 104(1) , 19-29, (2010) The dinuclear aminopeptidase from Streptomyces griseus (SgAP) and its metal derivatives catalyze the hydrolysis of the phosphoester bis(p-nitrophenyl) phosphate (BNPP) and the phosphonate ester p-nitrophenyl phenylphosphonate with extraordinary rate enhanceme... |
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Crystal structure of an EAL domain in complex with reaction product 5'-pGpG.
PLoS ONE 7(12) , e52424, (2012) FimX is a large multidomain protein containing an EAL domain and involved in twitching motility in Pseudomonas aeruginosa. We present here two crystallographic structures of the EAL domain of FimX (residues 438-686): one of the apo form and the other of a com... |
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Contribution of carboxylesterase in hamster to the intestinal first-pass loss and low bioavailability of ethyl piperate, an effective lipid-lowering drug candidate.
Drug Metab. Dispos. 39(5) , 796-802, (2011) Ethyl piperate is an effective lipid-lowering drug candidate synthesized from piperine. However, its pharmacokinetic characteristics and oral absorption process remain unclear. A liquid chromatography-tandem mass spectrometry method was applied to determine t... |
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Evolution in the amidohydrolase superfamily: substrate-assisted gain of function in the E183K mutant of a phosphotriesterase-like metal-carboxylesterase.
Biochemistry 48(24) , 5602-12, (2009) The recent specialization for utilization of pesticides reported for Pseudomonas diminuta phosphotriesterase (pPTE) strongly suggests that this activity evolved from an enzyme endowed with promiscuous phosphotriesterase activity. Such a putative "generalist" ... |
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Influence of carboxylesterase 2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients.
Xenobiotica 39(5) , 407-14, (2009) Mycophenolic acid (MPA), converted from the prodrug mycophenolate mofetil (MMF), is generated by intestinal and hepatic esterases. The role of carboxylesterase (CES) in MMF hydrolysis was examined in vitro using human liver microsomes. V(max) and K(m) values ... |
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Carboxylesterase expression in human dental pulp cells: role in regulation of BisGMA-induced prostanoid production and cytotoxicity.
Acta Biomater. 8(3) , 1380-7, (2012) Biocompatibility of dentin bonding agents (DBA) and composite resin may affect the treatment outcome (e.g., healthy pulp, pulpal inflammation, pulp necrosis) after operative restoration. Bisphenol-glycidyl methacrylate (BisGMA) is one of the major monomers pr... |
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Crystal structure of Ce(IV)/dipicolinate complex as catalyst for DNA hydrolysis.
J. Biol. Inorg. Chem. 13(2) , 249-55, (2008) The structures of Ce(4+) complexes that are active for DNA hydrolysis were determined for the first time by X-ray crystallography. The crystals were prepared from a 1:2 mixture of Ce(NH(4))(2)(NO(3))(6) and dipicolinic acid (2,6-pyridinedicarboxylic acid). De... |
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Ontogeny of acylated ghrelin degradation in the rat.
Peptides 31(2) , 301-6, (2010) Ghrelin circulates as acylated (AG) and unacylated (or desacyl) ghrelin (UAG). We aimed at clarifying the effect of age and sex on plasma deacylation and degradation of AG in vivo and in vitro in the rat. In vivo, we compared AG and UAG concentrations followi... |