6-Keto cholestanol
6-Keto cholestanol structure
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Common Name | 6-Keto cholestanol | ||
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| CAS Number | 1175-06-0 | Molecular Weight | 402.65300 | |
| Density | 1 g/cm3 | Boiling Point | 501.3ºC at 760 mmHg | |
| Molecular Formula | C27H46O2 | Melting Point | 140-142 °C | |
| MSDS | USA | Flash Point | 212.4ºC | |
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SR4 Uncouples Mitochondrial Oxidative Phosphorylation, Modulates AMP-dependent Kinase (AMPK)-Mammalian Target of Rapamycin (mTOR) Signaling, and Inhibits Proliferation of HepG2 Hepatocarcinoma Cells.
J. Biol. Chem. 290 , 30321-41, (2015) Mitochondrial oxidative phosphorylation produces most of the energy in aerobic cells by coupling respiration to the production of ATP. Mitochondrial uncouplers, which reduce the proton gradient across the mitochondrial inner membrane, create a futile cycle of... |
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Probing amphotericin B single channel activity by membrane dipole modifiers.
PLoS ONE 7(1) , e30261, (2012) The effects of dipole modifiers and their structural analogs on the single channel activity of amphotericin B in sterol-containing planar phosphocholine membranes are studied. It is shown that the addition of phloretin in solutions bathing membranes containin... |
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Effect of agents modifying the membrane dipole potential on properties of syringomycin E channels.
Langmuir 23(13) , 6889-92, (2007) We evaluated the effect of agents modifying the membrane dipole potential: phloretin, 6-ketocholestanol and RH 421 on the properties of single channels formed by lipodepsipeptide syringomycin E (SRE) in planar lipid bilayers. SRE forms two conductive states i... |
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Effect of dipole modifiers on the kinetics of sensitized photoinactivation of gramicidin channels in bilayer lipid membranes.
Membr. Cell Biol. 13(1) , 111-20, (1999) Photodynamic inactivation of gramicidin channels in bilayer lipid membranes induced by single flashes of the visible light in the presence of phthalocyanine has been studied. The kinetic curves of the flash-induced decrease in the gramicidin-mediated electric... |
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The uptake of HIV Tat peptide proceeds via two pathways which differ from macropinocytosis.
Biochim. Biophys. Acta 1848(3) , 869-77, (2015) Cell penetrating peptides (CPPs) have been extensively studied as vectors for cellular delivery of therapeutic molecules, yet the identity of their uptake routes remained unclear and is still under debate. In this study we provide new insights into CPP entry ... |
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Mimicking respiratory phosphorylation using purified enzymes.
Biochim. Biophys. Acta 1857 , 321-31, (2016) The enzymes of oxidative phosphorylation is a striking example of the functional association of multiple enzyme complexes, working together to form ATP from cellular reducing equivalents. These complexes, such as cytochrome c oxidase or the ATP synthase, are ... |
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The local electric field within phospholipid membranes modulates the charge transfer reactions in reaction centres.
Biochim. Biophys. Acta 1787 , 1039-1049, (2009) Three different cholesterol derivatives and phloretin, known to affect the local electric field in phospholipid membranes, have been introduced into Rhodobacter sphaeroides reaction centre-containing phospholipid liposomes. We show that cholesterol and 6-keto... |
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Sterol structure and sphingomyelin acyl chain length modulate lateral packing elasticity and detergent solubility in model membranes.
Biophys. J. 85(6) , 3788-801, (2003) Membrane microdomains, such as caveolae and rafts, are enriched in cholesterol and sphingomyelin, display liquid-ordered phase properties, and putatively function as protein organizing platforms. The goal of this investigation was to identify sterol and sphin... |
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Influence of 6-ketocholestanol on skin permeation of 5-aminolevulinic acid and evaluation of chemical stability.
J. Pharm. Sci. 93(11) , 2780-7, (2004) The ability of 6-ketocholestanol to increase the skin permeation of the prodrug aminolevulinic acid (5-ALA) was investigated. 6-Ketocholestanol was incorporated together with 5-ALA in four different formulations. Preparations used were a liquid solution/suspe... |
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Phlorizin- and 6-ketocholestanol-mediated antagonistic modulation of alamethicin activity in phospholipid planar membranes.
Langmuir 22(20) , 8452-7, (2006) As a result of the interfacial chemical heterogenity, membrane-penetrating peptides will experience a dramatic variation in environmental polarity manifested via electrical interactions with the surface and dipole potential of membranes prone to modulate the ... |