4-Methylumbelliferylglucuronide
4-Methylumbelliferylglucuronide structure
|
Common Name | 4-Methylumbelliferylglucuronide | ||
|---|---|---|---|---|
| CAS Number | 6160-80-1 | Molecular Weight | 352.293 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 683.1±55.0 °C at 760 mmHg | |
| Molecular Formula | C16H16O9 | Melting Point | 102 °C | |
| MSDS | USA | Flash Point | 255.0±25.0 °C | |
|
Development of an enzyme assay for rapid assessment of Escherichia coli in seawaters.
J. Appl. Microbiol. 93(4) , 548-56, (2002) An analytical protocol has been developed and applied for the detection of glucuronidase activity in marine waters as a rapid alternative approach to assess the microbiological quality of seawaters.The fluorogenic substrate 4-methylumbelliferyl-beta-D-glucuro... |
|
|
An alternative approach for enumeration of Escherichia coli in foods.
Int. J. Food Microbiol. 68(3) , 217-23, (2001) An assay to screen Escherichia coli in foods using MUG supplemented lauryl sulfate tryptose (LST) broth instead of tryptone water (TW) medium was evaluated. The results presented in this paper suggest that this method is more sensitive for lower levels of E. ... |
|
|
Serogroup distribution and virulence characteristics of sorbitol-negative Escherichia coli from food and cattle stool.
J. Appl. Microbiol. 108(2) , 658-65, (2010) To (i) study the serogroup distribution and virulence characteristics of non-sorbitol-fermenting Escherichia coli isolates from foods of animal origin and cattle faeces and (ii) re-examine the true sorbitol and beta-D-glucuronidase (GUD) reactions of sorbitol... |
|
|
Differential disposition of intra-renal generated and preformed glucuronides: studies with 4-methylumbelliferone and 4-methylumbelliferyl glucuronide in the filtering and nonfiltering isolated perfused rat kidney.
J. Pharm. Pharmacol. 63(4) , 507-14, (2011) This study was designed to investigate the renal disposition of 4-methylumbelliferone (4MU) and 4-methylumbelliferyl glucuronide (4MUG) to characterise the contribution of excretion and metabolic clearance to total clearance in the kidney.The isolated perfuse... |
|
|
Evaluation of pharmaceutical excipients as cosolvents in 4-methyl umbelliferone glucuronidation in human liver microsomes: applications for compounds with low solubility.
Drug Metab. Pharmacokinet. 26(1) , 102-6, (2011) Standard incubation procedures for carrying out microsomal assays involve the use of less than 1% w/v organic solvents to minimize the potential inhibitory effects of organic solvents on metabolic activity. This presents a practical limitation for poorly solu... |
|
|
Utilization of fluorogenic assay for rapid detection of Escherichia coli in acidic fruit juice.
J. Food Prot. 65(12) , 1943-8, (2002) This study was undertaken to investigate interference by acids commonly found in fruit juice in Escherichia coli assays involving the use of 4-methylumbelliferyl-beta-D-glucuronide (MUG) as a fluorogenic substrate for enzyme reaction. Fluorescence intensity w... |
|
|
Expression of active human beta-glucuronidase in Sf9 cells infected with recombinant baculovirus.
Life Sci. 71(13) , 1547-57, (2002) Antibody directed enzyme prodrug therapy (ADEPT) using glucuronide prodrugs is an experimental approach to reduce systemic toxicity of anti-cancer agents. Bioactivation of such prodrugs is achieved by fusion proteins consisting of targeting moieties (e.g. lig... |
|
|
Verapamil regulates activity and mRNA-expression of human beta-glucuronidase in HepG2 cells.
Naunyn Schmiedebergs Arch. Pharmacol. 368(6) , 463-9, (2003) A promising development in tumor therapy is the application of non-toxic prodrugs from which the active cytostatic is released by endogenous enzymes such as beta-glucuronidase (beta-gluc). Regulation of beta-gluc expression is one crucial factor modulating bi... |
|
|
Rapid methods to enumerate Escherichia coli in foods using 4-methylumbelliferyl-beta-D-glucuronide.
J. AOAC Int. 84(2) , 407-15, (2001) Three methods to enumerate Escherichia coli in food were compared. They were based on AOAC methods using lauryl tryptose broth (LST) medium, LST-4-methylumbelliferyl-beta-D-glucuronide (MUG) medium, and a proposed method using regular LST in combination with ... |
|
|
Pharmacokinetic analysis of factors determining elimination pathways for sulfate and glucuronide metabolites of xenobiotics. III: mechanisms for sinusoidal efflux of 4-methylumbelliferone sulfate.
Xenobiotica 34(5) , 439-48, (2004) 1. To elucidate the mechanisms involved in the sinusoidal efflux of sulfate and glucuronide metabolites of 4-methylumbelliferone (4MU), isolated rat liver perfusion studies were performed under several conditions. 2. The effect of sodium azide on the hepatic ... |