2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one
![2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one Structure](https://image.chemsrc.com/caspic/212/27277-00-5.png)
2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one structure
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Common Name | 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one | ||
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| CAS Number | 27277-00-5 | Molecular Weight | 207.23200 | |
| Density | 1.44g/cm3 | Boiling Point | 459.9ºC at 760 mmHg | |
| Molecular Formula | C9H13N5O | Melting Point | 161.8-163ºC | |
| MSDS | USA | Flash Point | 231.9ºC | |
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Characteristic behavioural alterations in rats induced by rolipram and other selective adenosine cyclic 3', 5'-monophosphate phosphodiesterase inhibitors.
Psychopharmacology 77(4) , 309-16, (1982) The significance of a characteristic symptomatology (hypothermia, hypoactivity, forepaw shaking, grooming, head twitches) as a potential in vivo correlate of enhanced availability of brain adenosine cyclic 3',5'-monophosphate (cAMP) was examined in rats follo... |
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Rolipram, a novel antidepressant drug, reverses the hypothermia and hypokinesia of monoamine-depleted mice by an action beyond postsynaptic monoamine receptors.
Neuropharmacology 25(10) , 1119-26, (1986) The antidepressant potential of rolipram and inhibitors of phosphodiesterase (PDE) which are selective for cyclic AMP has previously been ascribed to enhancement of central noradrenergic transmission by the combination of two mechanisms of action: increase of... |
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Effects of isoprenaline, levodopa and a phosphodiesterase inhibitor (ICI 63,197) on cyclic AMP levels and contractions of soleus muscles in anesthetized cats.
Clin. Exp. Pharmacol. Physiol. 8(1) , 57-66, (1981) 1. Cyclic AMP levels have been determined in the soleus muscles of anaesthetized cats in the absence of drugs, and during depression of incomplete tetanic contractions produced by (-)-isoprenaline, ICI 63,197 (a phosphodiesterase inhibitor) or levodopa. 2. Cy... |
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Effects of alpha- and beta-adrenoceptor agonists and a phosphodiesterase inhibitor (ICI 63 197) on cyclic AMP and GMP levels in bovine splenic nerve.
Clin. Exp. Pharmacol. Physiol. 10(1) , 35-44, (1983) 1. Cyclic AMP and cyclic GMP levels were determined in bovine splenic nerve segments in the absence and presence of (+/-)-isoprenaline, (-)-phenylephrine, clonidine and ICI 63 197 (a phosphodiesterase inhibitor). The chosen concentrations of adrenoceptor agon... |
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Character and meaning of quasi-morphine withdrawal phenomena elicited by methylxanthines.
Fed. Proc. 40(5) , 1513-8, (1981) A quasi-morphine withdrawal syndrome (QMWS) is a pattern of behavior closely resembling the true withdrawal syndrome in the opiate-dependent animal, which can be elicited acutely by a nonopiate drug in an opiate-naive animal. The main criteria proposed for th... |
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Role of cyclic AMP in stimulation-evoked release of 3H-noradrenaline from rabbit isolated ear artery.
Pharmacol. Toxicol. 76(3) , 185-9, (1995) The possible involvement of cyclic AMP in the stimulation-evoked 3H-overflow from rabbit isolated ear artery preloaded with 3H-noradrenaline was studied. Cyclic AMP (10(-5)-3 x 10(-4)M), 8-bromo-cyclic AMP (3 x 10(-4)M) and adenosine (10(-5)-3 x 10(-4)M) enha... |
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Impaired lymphocyte cyclic adenosine monophosphate responses in atopic eczema.
Br. J. Dermatol. 109(5) , 559-64, (1983) Peripheral blood lymphocyte cyclic AMP responses to isoprenaline, prostaglandin E2 and histamine were examined in patients with atopic eczema, in the presence and absence of a potent phosphodiesterase inhibitor (PDEI). Basal cyclic AMP levels were not signifi... |
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Inhibition of acid secretion in the rat isolated stomach preparation by 5-hydroxytryptamine.
Int. J. Tissue React. 5(3) , 241-3, (1983) The effect of 5 hydroxytryptamine (5-HT) on gastric acid secretion by the rat isolated stomach has been studied. 5-HT (10 microM) significantly inhibited secretory responses to pentagastrin, histamine and isoprenaline but not those due to bethanechol, dibutyr... |
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Lack of presynaptic modulation by isoprenaline of 3H-noradrenaline release from rabbit isolated ear artery.
Naunyn Schmiedebergs Arch. Pharmacol. 343(2) , 161-5, (1991) The aim of the present investigation was to examine whether or not presynaptic facilitatory beta-adrenoceptors are detectable on the postganglionic nerves in the rabbit isolated ear artery. Strips of rabbit central ear artery were incubated with 3H-noradrenal... |
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Role of cyclic AMP in cardiac beta-adrenoceptor desensitization: studies using prenalterol and inhibitors of phosphodiesterase.
J. Cardiovasc. Pharmacol. 6(5) , 795-801, (1984) We examined the effects of prolonged exposure of cardiac cells in primary culture to the partial beta-adrenoceptor agonist prenalterol and inhibitors of phosphodiesterase on their subsequent ability to increase intracellular cyclic AMP during a 5-min exposure... |