P-FLUORO-HEXAHYDRO-SILA-DIFENIDOL
P-FLUORO-HEXAHYDRO-SILA-DIFENIDOL structure
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Common Name | P-FLUORO-HEXAHYDRO-SILA-DIFENIDOL | ||
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| CAS Number | 116679-83-5 | Molecular Weight | 386.01900 | |
| Density | 1.07g/cm3 | Boiling Point | 447.5ºC at 760mmHg | |
| Molecular Formula | C20H33ClFNOSi | Melting Point | N/A | |
| MSDS | USA | Flash Point | 224.4ºC | |
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Muscarinic receptor subtypes involved in urothelium-derived relaxatory effects in the inflamed rat urinary bladder.
Auton. Neurosci. 170(1-2) , 5-11, (2012) Functional studies have shown altered cholinergic mechanisms in the inflamed bladder, which partly depend on muscarinic receptor-induced release of nitric oxide (NO). The current study aimed to characterize which muscarinic receptor subtypes that are involved... |
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Functional characterization of the muscarinic receptors involved in endothelium-dependent relaxation in isolated canine uterine artery.
J. Vet. Pharmacol. Ther. 32(2) , 109-15, (2009) Acetylcholine interacts with endothelial muscarinic receptors releasing nitric oxide and causing vasodilatation. To identify the receptor subtype responsible for acetylcholine-induced relaxation in canine uterine artery, the usual organ bath method for in vit... |
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Pharmacological characterization of muscarinic receptor subtypes mediating vasoconstriction of human umbilical vein.
Br. J. Pharmacol. 147(5) , 516-23, (2006) The present study attempted to pharmacologically characterize the muscarinic receptor subtypes mediating contraction of human umbilical vein (HUV).HUV rings were mounted in organ baths and concentration-response curves were constructed for acetylcholine (ACh)... |
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Acetylcholine-induced contractions in the porcine internal mammary artery: possible role of muscarinic receptors.
Zentralbl. Veterinarmed. A 46(8) , 509-15, (1999) The effect of acetylcholine on the isolated, non-precontracted, porcine internal mammary artery (IMA) was investigated. Acetylcholine induced concentration-dependent contractions of non-precontracted IMA rings with denuded endothelium (pEC50 = 5.80 +/- 0.04) ... |
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Contractile effect of acetylcholine on isolated isthmic segment of fallopian tubes.
Methods Find. Exp. Clin. Pharmacol. 26(2) , 87-91, (2004) The Fallopian tubes are sparsely innervated with cholinergic nerve fibers. Acetylcholine is released from these nerves and contracts the smooth muscles of the tubes. The aim of our study was to investigate the effect of acetylcholine on the isthmic segment of... |
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Aging-induced decrease of cholinergic response and calcium sensitivity on rat jejunum contractions.
J. Gerontol. A. Biol. Sci. Med. Sci. 62(3) , 264-70, (2007) The role of aging on contraction or relaxation through muscarinic or alpha-adrenergic receptors, respectively, was studied in isolated rat jejunum. Furthermore, the influence of extracellular calcium was analyzed, through functional and radioligand binding as... |
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The cholinomimetic agent bethanechol activates IK(ACh) in feline atrial myocytes.
Naunyn Schmiedebergs Arch. Pharmacol. 368(4) , 309-15, (2003) The effect of the cholinomimetic agent, bethanechol on macroscopic membrane currents was studied in dispersed cat atrial myocytes, using the whole-cell patch-clamp technique. Bethanechol activated an inward rectifying potassium current similar to I(K(ACh)), a... |
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Ascending neural pathways in the isolated guinea-pig ileum: effect of muscarinic M1, M2 and M3 cholinergic antagonists.
Neuroscience 91(4) , 1575-80, (1999) The effect of muscarinic cholinoceptor antagonists was investigated on the ascending neural pathways activated by electrical stimulation in the guinea-pig ileum. For comparison, prejunctional and postjunctional effects of muscarinic cholinoceptor antagonists ... |
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Muscarinic receptors control K+ secretion in inner ear strial marginal cells.
J. Membr. Biol. 182(3) , 171-81, (2001) K+ secretion in strial marginal cells (SMC) of stria vascularis (SV) is stimulated by beta1-adrenergic receptors. The aim of the present study was to determine, whether SMC from the gerbil inner ear contain muscarinic receptors that inhibit K+ secretion. Rece... |
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Muscarinic receptor subtypes mediating vasorelaxation of the perforating branch of the human internal mammary artery.
Pharmacology 63(3) , 185-90, (2001) The effect of acetylcholine (ACh) on the isolated perforating branch of the human internal mammary artery (HIMA) was investigated. ACh induced concentration- and endothelium-dependent relaxation of arterial rings precontracted with phenylephrine (pEC(50) = 6.... |