Benzo[c]chrysene
![Benzo[c]chrysene Structure](https://image.chemsrc.com/caspic/495/194-69-4.png)
Benzo[c]chrysene structure
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Common Name | Benzo[c]chrysene | ||
|---|---|---|---|---|
| CAS Number | 194-69-4 | Molecular Weight | 278.347 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 524.7±17.0 °C at 760 mmHg | |
| Molecular Formula | C22H14 | Melting Point | 126.5°C | |
| MSDS | N/A | Flash Point | 264.5±15.1 °C | |
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Covalent DNA adducts formed by benzo[c]chrysene in mouse epidermis and by benzo[c]chrysene fjord-region diol epoxides reacted with DNA and polynucleotides.
Chem. Res. Toxicol. 10(11) , 1275-84, (1997) The metabolic activation in mouse skin of benzo[c]chrysene (B[c]C), a weakly carcinogenic polycyclic aromatic hydrocarbon (PAH) present in coal tar and crude oil, was investigated. Male Parkes mice were treated topically with 0.5 mumol of B[c]C, and DNA was i... |
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Metabolism of benzo[c]chrysene and comparative mammary gland tumorigenesis of benzo[c]chrysene bay and fjord region diol epoxides in female CD rats.
Chem. Res. Toxicol. 16(2) , 227-31, (2003) Benzo[c]chrysene (BcC), an environmental pollutant, is a unique polycyclic aromatic hydrocarbon that possesses both a bay region and a fjord region in the same molecule. We previously demonstrated that both bay region and fjord region terminal rings are invol... |
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Synthesis of fjord region tetraols and their use in hepatic biotransformation studies of dihydrodiols of benzo[c]chrysene, benzo[g]chrysene and dibenzo[a,l]pyrene.
Carcinogenesis 19(4) , 639-48, (1998) Metabolic activation of the racemic benzo[c]chrysene-trans-9,10-, benzo[g]chrysene-trans-11,12- and dibenzo[a,l]pyrene-trans-11,12-dihydrodiols to fjord region syn- and anti-dihydrodiol epoxides by microsomes of Aroclor 1254-treated Sprague-Dawley rats has be... |
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Location of the epoxide function determines specificity of the allelic variants of human glutathione transferase Pi toward benzo[c]chrysene diol epoxide isomers.
FEBS Lett. 486(2) , 163-6, (2000) Carcinogenic activity of many polycyclic aromatic hydrocarbons (PAHs) is mainly attributed to their respective diol epoxides, which can be classified as either bay or fjord region depending upon the location of the epoxide function. The Pi class human glutath... |