Hematin
Hematin structure
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Common Name | Hematin | ||
|---|---|---|---|---|
| CAS Number | 15489-90-4 | Molecular Weight | 633.495 | |
| Density | N/A | Boiling Point | 1128.5ºC at 760 mmHg | |
| Molecular Formula | C34H33FeN4O5 | Melting Point | 180ºC | |
| MSDS | USA | Flash Point | 636.3ºC | |
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In vivo antimalarial activity and mechanisms of action of 4-nerolidylcatechol derivatives.
Antimicrob. Agents Chemother. 59 , 3271-80, (2015) 4-Nerolidylcatechol (1) is an abundant antiplasmodial metabolite that is isolated from Piper peltatum roots. O-Acylation or O-alkylation of compound 1 provides derivatives exhibiting improved stability and significant in vitro antiplasmodial activity. The aim... |
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Glycan complexity dictates microbial resource allocation in the large intestine.
Nat. Commun. 6 , 7481, (2015) The structure of the human gut microbiota is controlled primarily through the degradation of complex dietary carbohydrates, but the extent to which carbohydrate breakdown products are shared between members of the microbiota is unclear. We show here, using xy... |
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The Qiagen Investigator® Quantiplex HYres as an alternative kit for DNA quantification.
Forensic Sci. Int. Genet. 16 , 148-62, (2015) The Investigator® Quantiplex HYres kit was evaluated as a potential replacement for dual DNA quantification of casework samples. This kit was determined to be highly sensitive with a limit of quantification and limit of detection of 0.0049ng/μL and 0.0003ng/μ... |
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Rapid and specific drug quality testing assay for artemisinin and its derivatives using a luminescent reaction and novel microfluidic technology.
Am. J. Trop. Med. Hyg. 92 , 24-30, (2015) Globally, it is estimated that about 10-30% of pharmaceuticals are of poor quality. Poor-quality drugs lead to long-term drug resistance, create morbidity, and strain the financial structure of the health system. The current technologies for substandard drug ... |
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The Ancient Immunoglobulin Domains of Peroxidasin Are Required to Form Sulfilimine Cross-links in Collagen IV.
J. Biol. Chem. 290 , 21741-8, (2015) The collagen IV sulfilimine cross-link and its catalyzing enzyme, peroxidasin, represent a dyad critical for tissue development, which is conserved throughout the animal kingdom. Peroxidasin forms novel sulfilimine bonds between opposing methionine and hydrox... |
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Ultrahigh-performance liquid chromatography/tandem mass spectrometry method for evaluating enzyme activity and screening inhibitors of cyclooxygenase-2.
Rapid Commun. Mass Spectrom. 28(16) , 1792-800, (2015) Prostaglandin E2 is an important biomarker in many biological systems. The development of sensitive and reliable analytical methods for monitoring PGE2 contents in various samples is of great interest. Here we developed an improved method for evaluating the e... |
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Functionalized magnetic nanoparticles coupled with mass spectrometry for screening and identification of cyclooxygenase-1 inhibitors from natural products.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 960 , 126-32, (2014) Development of simple and effective methods for high-throughput, high-fidelity screening and identification of cyclooxygenase-1 (COX-1) inhibitors from natural products are important for drug discovery to treat inflammation and carcinogenesis. Here, we develo... |
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Prospective performance evaluation of selected common virtual screening tools. Case study: Cyclooxygenase (COX) 1 and 2.
Eur. J. Med. Chem. 96 , 445-57, (2015) Computational methods can be applied in drug development for the identification of novel lead candidates, but also for the prediction of pharmacokinetic properties and potential adverse effects, thereby aiding to prioritize and identify the most promising com... |
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Pharmacophore modeling for COX-1 and -2 inhibitors with LigandScout in comparison to Discovery Studio.
Future Med. Chem. 6(17) , 1869-81, (2014) Pharmacophore modeling has become an integrated tool in drug discovery. However, no prospective study compares the performance of the available software.The two widely used pharmacophore modeling and screening software programs Discovery Studio and LigandScou... |
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In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens.
Antimicrob. Agents Chemother. 52 , 1653-62, (2008) Rx-01_423 and Rx-01_667 are two members of the family of oxazolidinones that were designed using a combination of computational and medicinal chemistry and conventional biological techniques. The compounds have a two- to eightfold-improved potency over linezo... |