Letrozole
Letrozole structure
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Common Name | Letrozole | ||
|---|---|---|---|---|
| CAS Number | 112809-51-5 | Molecular Weight | 263.337 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 472.0±55.0 °C at 760 mmHg | |
| Molecular Formula | C17H11N5 | Melting Point | 181-183ºC | |
| MSDS | Chinese USA | Flash Point | 214.2±24.5 °C | |
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Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance.
Carcinogenesis 36(1) , 122-32, (2015) Response to breast cancer chemoprevention can depend upon host genetic makeup and initiating events leading up to preneoplasia. Increased expression of aromatase and estrogen receptor (ER) is found in conjunction with breast cancer. To investigate response or... |
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Hypogonadism Associated with Cyp19a1 (Aromatase) Posttranscriptional Upregulation in Celf1 Knockout Mice.
Mol. Cell. Biol. 35 , 3244-53, (2015) CELF1 is a multifunctional RNA-binding protein that controls several aspects of RNA fate. The targeted disruption of the Celf1 gene in mice causes male infertility due to impaired spermiogenesis, the postmeiotic differentiation of male gametes. Here, we inves... |
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Aromatase (Cyp19a1b) in the pituitary is dynamically involved in the upregulation of lhb but not fshb in the vitellogenic female ricefield eel Monopterus albus.
Endocrinology 155(11) , 4531-41, (2014) Aromatase, encoded by Cyp19a1, is expressed in the pituitary of vertebrates; however, its physiological relevance remains poorly defined. In teleosts, the duplicated cyp19a1b is preferentially expressed in the pituitary where LH and FSH are synthesized in dis... |
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Aurora kinase A and B as new treatment targets in aromatase inhibitor-resistant breast cancer cells.
Breast Cancer Res. Treat. 149(3) , 715-26, (2015) Aromatase inhibitors (AIs) are used for treatment of estrogen receptor α (ER)-positive breast cancer; however, resistance is a major obstacle for optimal outcome. This preclinical study aimed at identifying potential new treatment targets in AI-resistant brea... |
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Bu-Shen-Ning-Xin Decoction ameliorated the osteoporotic phenotype of ovariectomized mice without affecting the serum estrogen concentration or uterus.
Drug Des. Devel. Ther. 9 , 5019-31, (2015) Bu-Shen-Ning-Xin Decoction (BSNXD), a traditional Chinese medicinal composition, has been used as a remedy for postmenopausal osteoporosis, but its effects on bone metabolism and the uterus have not been reported.We aimed to determine the respective effects o... |
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Complex effects of two presumably antagonistic endocrine disrupting compounds on the goldfish Carassius aumtus: a comprehensive study with multiple toxicological endpoints.
Aquat. Toxicol. 155 , 43-51, (2014) We studied the effects of endocrine disrupting compounds nonylphenol (NP) and letrozole (LE) on the male goldfish Carassius aumtus. Exposure to NP (20 μg l(-1)) alone caused a significant up-regulation in the expression of aromatase, estrogen receptors and vi... |
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New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulvestrant treatment and cross-resistance between letrozole and exemestane.
Int. J. Oncol. 46(4) , 1481-90, (2015) Aromatase inhibitor (AI) treatment is first-line systemic treatment for the majority of postmenopausal breast cancer patients with estrogen receptor (ER)-positive primary tumor. Although many patients benefit from treatment, some will develop resistance, and ... |
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Prenatal hyperandrogenic environment induced autistic-like behavior in rat offspring.
Physiol. Behav. 138 , 13-20, (2014) Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by persistent impairment in social communication and social interaction. Recent studies revealed that environmental factors, especially the intrauterine developmental environment, p... |
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Neuroestradiol in the hypothalamus contributes to the regulation of gonadotropin releasing hormone release.
J. Neurosci. 33(49) , 19051-9, (2013) Release of gonadotropin releasing hormone (GnRH) from the medial basal hypothalamus (MBH)/median eminence region (S-ME) is essential for normal reproductive function. GnRH release is profoundly regulated by the negative and positive feedback effects of ovaria... |
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Long-Term Outcome of Aromatase Inhibitor Therapy With Letrozole in Patients With Advanced Low-Grade Endometrial Stromal Sarcoma.
Int. J. Gynecol. Cancer 25 , 1645-51, (2015) There has been no consensus on the indications for the treatment of advanced low-grade endometrial stromal sarcoma (LGESS), and the possible effects of hormonal treatment including progestins and aromatase inhibitors have been reported. The aim of this study ... |