4-(hydroxymethyl)-d-phenylalanine
4-(hydroxymethyl)-d-phenylalanine structure
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Common Name | 4-(hydroxymethyl)-d-phenylalanine | ||
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| CAS Number | 15720-17-9 | Molecular Weight | 195.21500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H13NO3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Tetrapeptide tyrosine kinase inhibitors. Enantioselective synthesis of p-hydroxymethyl-L-phenylalanine, incorporation into a tetrapeptide, and subsequent elaboration into p-(R,S-hydroxyphosphonomethyl)-L-phenylalanine.
Int. J. Pept. Protein Res. 44(5) , 457-65, (1994) A convenient enantioselective synthesis of p-hydroxymethyl-L-phenylalanine was developed which produces a 4/1 ratio of L/D enantiomers resulting from a chiral phase-transfer-catalyzed alkylation. This amino acid was coupled into the p56(1)ck tyrosine kinase s... |
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Analogs of arginine vasopressin modified in position 3 with (R)-alpha-hydroxymethylphenylalanine.
J. Pept. Res. 53(5) , 554-9, (1999) This study describes the synthesis and some pharmacological properties of three new analogs of arginine vasopressin (AVP) substituted in position 3 with (R)-alpha-hydroxymethylphenylalanine ([R]-HmPhe). All new peptides were tested for vasopressor and antidiu... |
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DALDA analogues containing alpha-hydroxymethylamino acids.
Acta Biochim. Pol. 48(4) , 1121-4, (2001) To evaluate the role of aromatic amino-acids residues, four analogues of the mu-selective opioid peptide agonist DALDA (H-Tyr-D-Arg-Phe-Lys-NH2) containing the amphiphilic, a,a-disubstituted amino acid (R)- or (S)-alpha-hydroxymethyltyrosine (HmTyr) in positi... |