THYMIDYLYL(3'->5')THYMIDINE AMMONIUM SALT
THYMIDYLYL(3'->5')THYMIDINE AMMONIUM SALT structure
|
Common Name | THYMIDYLYL(3'->5')THYMIDINE AMMONIUM SALT | ||
|---|---|---|---|---|
| CAS Number | 1969-54-6 | Molecular Weight | 546.42200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H27N4O12P | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
|
Oligonucleotide treatment increases eumelanogenesis, hair pigmentation and melanocortin-1 receptor expression in the hair follicle.
Exp. Dermatol. 16(8) , 671-7, (2007) It was previously reported that telomere homologue oligonucleotides (T-oligos) can induce a variety of cellular responses in skin including increased melanogenesis. To assess the effects of T-oligos on hair pigmentation, we administered thymidine dinucleotide... |
|
|
Complete stereospecific repair of a synthetic dinucleotide spore photoproduct by spore photoproduct lyase.
J. Biol. Inorg. Chem. 15(6) , 943-55, (2010) Spore photoproduct lyase (SP lyase), a member of the radical S-adenosylmethionine superfamily of enzymes, catalyzes the repair of 5-thyminyl-5,6-dihydrothymine [spore photoproduct (SP)], a type of UV-induced DNA damage unique to bacterial spores. The anaerobi... |
|
|
The ability of a variety of polymerases to synthesize past site-specific cis-syn, trans-syn-II, (6-4), and Dewar photoproducts of thymidylyl-(3'-->5')-thymidine.
J. Biol. Chem. 273(34) , 21933-40, (1998) The role of photoproduct structure, 3' --> 5' exonuclease activity, and processivity on polynucleotide synthesis past photoproducts of thymidylyl-(3' --> 5')-thymidine was investigated. Both Moloney murine leukemia virus reverse transcriptase and 3' --> 5' ex... |
|
|
Mutation spectra of M13 vectors containing site-specific Cis-Syn, Trans-Syn-I, (6-4), and Dewar pyrimidone photoproducts of thymidylyl-(3'-->5')-thymidine in Escherichia coli under SOS conditions.
Biochemistry 35(13) , 4146-54, (1996) The mutations spectra of cis-syn, trans-syn-I, (6-4), and Dewar pyrimidone photoproducts of the TT site of AATTAA and TATTAT in the (-) strand of a heteroduplex M13 vector were obtained in an excision and photoreversal repair deficient Escherichia coli host u... |
|
|
Sugar conformational effects on the photochemistry of thymidylyl(3'-5')thymidine.
J. Org. Chem. 68(17) , 6502-10, (2003) The synthesis and conformational analysis of 2'-O,5-dimethyluridylyl(3'-5')-2'-O,5-dimethyluridine (1a), the analogue of thymidylyl(3'-5')thymidine (TpT; 1b) in which a methoxy group replaces each 2'-alpha-hydrogen atom, are described. In comparison with TpT,... |
|
|
Electrospray-mass spectrometry characterization and measurement of far-UV-induced thymine photoproducts.
J. Photochem. Photobiol. B, Biol. 54(2-3) , 145-54, (2000) Far-UV-induced formation of dimeric pyrimidine photoproducts within DNA is a major cause of the carcinogenic effects of solar light. The chemical structure of this class of lesion has been mostly determined by studies on model compounds. The present work is a... |
|
|
Selective recognition of thymidylylthymidine (TpT) and antitumor effects of a macrocyclic dizinc(II) complex.
Org. Biomol. Chem. 1(23) , 4242-7, (2003) A polyamino dizinc(II) complex, [(N-bisdien)Zn2(II)Cl2](ClO4)2, (LZn), has been synthesized as a new nucleobase receptor molecule in aqueous solution at physiological pH, and shows to be highly selective in recognizing deoxythymidine (dT) and thymidylylthymid... |
|
|
The Dewar photoproduct of thymidylyl(3'-->5')- thymidine (Dewar product) exhibits mutagenic behavior in accordance with the "A rule".
Proc. Natl. Acad. Sci. U. S. A. 97(9) , 4591-6, (2000) In contrast to the highly mutagenic pyrimidine(6-4)pyrimidone photoproduct, its Dewar valence isomer (Dewar product) has low mutagenic potential and produces a broad range of mutations [LeClerc, J. E., Borden, A. & Lawrence, C. W. (1991) Proc. Natl. Acad. Sci... |
|
|
The solution structure of DNA decamer duplex containing the Dewar product of thymidylyl(3-->5')thymidine by NMR and full relaxation matrix refinement.
FEBS Lett. 428(3) , 269-74, (1998) The (6-4) adducts and their Dewar isomers play an important role in cytotoxicity and mutation in skin cells exposed to sunlight. Structural study of the DNA duplex containing a site-specific photoproduct is an essential step toward understanding the molecular... |
|
|
Optical detection of thymine dinucleoside monophosphate and its cis-syn photodimer by inorganic nanoparticles.
J. Fluoresc. 14(4) , 407-15, (2004) The Watson-Crick DNA double helix is an averaged ideal of multitudinous natural sequence-directed local structural deviations. By effectively derailing normal cellular physiological processes, damaged bases can induce noncanonical irregularities in the local ... |