NVP-BHG 712

更新时间:2024-01-02 17:48:44

NVP-BHG 712结构式
NVP-BHG 712结构式
品牌特惠专场
常用名 NVP-BHG 712 英文名 NVP-BHG712
CAS号 940310-85-0 分子量 503.478
密度 1.4±0.1 g/cm3 沸点 N/A
分子式 C26H20F3N7O 熔点 N/A
MSDS 中文版 美版 闪点 N/A
符号 GHS06
GHS06
信号词 Danger

 NVP-BHG 712用途


NVP-BHG712是EphB4抑制剂,ED50为25 nM,对c-Raf,c-Src和c-Abl的IC50分别为0.395 μM,1.266 μM和1.667 μM。

 NVP-BHG 712名称

中文名 4-甲基-3-[[1-甲基-6-(3-吡啶基)-1H-吡唑并[3,4-d]嘧啶-4-基]氨基]-N-[3-(三氟甲基)苯基]苯甲酰胺
英文名 4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide
英文别名 更多

 NVP-BHG 712生物活性

描述 NVP-BHG712是EphB4抑制剂,ED50为25 nM,对c-Raf,c-Src和c-Abl的IC50分别为0.395 μM,1.266 μM和1.667 μM。
相关类别
参考文献

[1]. Martiny-Baron G, et al. The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis. Angiogenesis. 2010 Sep;13(3):259-67.

 NVP-BHG 712物理化学性质

密度 1.4±0.1 g/cm3
分子式 C26H20F3N7O
分子量 503.478
精确质量 503.168152
PSA 101.11000
LogP 4.05
外观性状 white to beige
折射率 1.666
储存条件 ?20°C
水溶解性 DMSO: >15mg/mL

 NVP-BHG 712安全信息

符号 GHS06
GHS06
信号词 Danger
危害声明 H301
警示性声明 P301 + P310
危害码 (欧洲) T
风险声明 (欧洲) 25
安全声明 (欧洲) 45
危险品运输编码 UN 2811 6.1 / PGIII

 NVP-BHG 712文献3

更多文献
EphB4 forward signalling regulates lymphatic valve development.

Nat. Commun. 6 , 6625, (2015)

Bidirectional signalling is regarded as a notable hallmark of the Eph-ephrin signalling system: Eph-dependent forward signalling in Eph-expressing cells and ephrin-dependent reverse signalling in Ephr...

EPHB4 Protein Expression in Vascular Smooth Muscle Cells Regulates Their Contractility, and EPHB4 Deletion Leads to Hypotension in Mice.

J. Biol. Chem. 290 , 14235-44, (2015)

EPH kinases are the largest family of receptor tyrosine kinases, and their ligands, ephrins (EFNs), are also cell surface molecules. This work presents evidence that EPHB4 on vascular smooth muscle ce...

Effect of EPH-ephrin signaling on the growth of human leukemia cells.

Anticancer Res. 34(6) , 2913-8, (2014)

Signaling induced by binding of erythropoietin-producing hepatoma-amplified sequence (EPH) receptors to their cell-surface ephrin ligands is implicated in hematopoiesis and growth of various cancer ce...

 NVP-BHG 712英文别名

NVP-BHG712
4-Methyl-3-{[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino}-N-[3-(trifluoromethyl)phenyl]benzamide
4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide
cc-540
S2202_Selleck
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