PPQ-102

• 常用名: PPQ-102
• 英文名: PPQ 102
• CAS号: 931706-15-9
• 分子量: 438.478
• 密度: 1.4±0.1 g/cm3
• 沸点: 648.7±65.0 °C at 760 mmHg
• 分子式: C₂₆H₂₂N₄O₃
• 熔点: N/A
• 闪点: 346.1±34.3 °C

PPQ-102用途

PPQ-102是CFTR抑制剂,能抑制CFTR氯流,IC50为90 nM。

PPQ-102名称

• 中文名: PPQ-102
• 英文名: 7,9-Dimethyl-6-(5-methyl-2-furyl)-11-phenyl-6,7-dihydropyrimido[4 ',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9H)-dione

PPQ-102生物活性

• 描述: PPQ-102是CFTR抑制剂,能抑制CFTR氯流,IC50为90 nM。
• 相关类别:
  信号通路 >> 跨膜转运 >> CFTR
  研究领域 >> 其他
• 参考文献:

  [1]. Tradtrantip L, et al. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J Med Chem. 2009 Oct 22;52(20):6447-55.

  [2]. Stewart AK, et al. SLC26 anion exchangers of guinea pig pancreatic duct: molecular cloning and functional characterization. Am J Physiol Cell Physiol. 2011 Aug;301(2):C289-303.

  [3]. Martin C, et al. CFTR dysfunction induces vascular endothelial growth factor synthesis in airway epithelium. Eur Respir J. 2013 Dec;42(6):1553-62.

PPQ-102物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 648.7±65.0 °C at 760 mmHg
• 分子式: C₂₆H₂₂N₄O₃
• 分子量: 438.478
• 闪点: 346.1±34.3 °C
• 精确质量: 438.169189
• PSA: 74.10000
• LogP: 3.48
• 外观性状: white solid
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.720
• 储存条件: -20℃

PPQ-102英文别名

• 7,9-Dimethyl-6-(5-methyl-2-furyl)-11-phenyl-6,7-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9H)-dione
• Pyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9H)-dione, 6,7-dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenyl-
• 7.9-Dimethylxanthin
• 7,9-dimethoxy-5H-pyrido<3,2-c>azepine
• 7,9-dimethylxanthine
• 7,9-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purinium betaine
• 7,9-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purinium-betain
• 7,9-dimethoxy-5H-pyrido<3,2-c>-azephine
• 3,9-dimethylxanthine
• PPQ-102