LUF6000

• 常用名: LUF6000
• 英文名: LUF6000
• CAS号: 890087-21-5
• 分子量: 411.32700
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₀Cl₂N₄
• 熔点: N/A
• 闪点: N/A

LUF6000用途

LUF6000是人A3腺苷受体变构调节剂。

LUF6000名称

• 中文名: LUF6000
• 英文名: 2-cyclohexyl-N-(3,4-dichlorophenyl)-3H-imidazo[4,5-c]quinolin-4-amine

LUF6000生物活性

• 描述: LUF6000是人A3腺苷受体变构调节剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Gao ZG, Verzijl D, Zweemer A et al. Functionally biased modulation of A(3) adenosine receptor agonist efficacy and potency by imidazoquinolinamine allosteric enhancers. Biochem Pharmacol. 2011 Sep 15;82(6):658-68. doi: 10.1016/j.bcp.2011.06.017.

  [2]. Szentmiklósi AJ, Cseppento A, Harmati G, Nánási PP. Novel trends in the treatment of cardiovascular disorders: site- and event- selective adenosinergic drugs. Curr Med Chem. 2011;18(8):1164-87.

  [3]. Heitman LH, G?bly?s A, Zweemer AM, et al. A series of 2,4-disubstituted quinolines as a new class of allosteric enhancers of the adenosine A3 receptor. J Med Chem. 2009 Feb 26;52(4):926-31.

  [4]. Gao ZG, Ye K, G?bly?s A, et al. Flexible modulation of agonist efficacy at the human A3 adenosine receptor by the imidazoquinoline allosteric enhancer LUF6000. BMC Pharmacol. 2008 Dec 12;8:20.

  [5]. G?bly?s A, Gao ZG, Brussee J, et al. Structure-activity relationships of new 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric enhancers of the A3 adenosine receptor. J Med Chem. 2006 Jun 1;49(11):3354-61.

LUF6000物理化学性质

• 分子式: C₂₂H₂₀Cl₂N₄
• 分子量: 411.32700
• 精确质量: 410.10700
• PSA: 56.83000
• LogP: 6.63110
• InChIKey: UWJVRSIGHHSDSJ-UHFFFAOYSA-N
• SMILES: Clc1ccc(Nc2nc3ccccc3c3nc(C4CCCCC4)[nH]c23)cc1Cl
• 储存条件: 2-8℃

LUF6000英文别名

• luf6000||luf 6000
• cs-1158
• luf6000