阿奇霉素

阿奇霉素结构式
阿奇霉素
常用名 阿奇霉素 英文名 Azithromycin
CAS号 83905-01-5 分子量 748.984
密度 1.2±0.1 g/cm3 沸点 822.1±65.0 °C at 760 mmHg
分子式 C38H72N2O12 熔点 113-115°C
MSDS阿奇霉素的MSDS|SDS|pdf下载 中文版 美版 闪点 451.0±34.3 °C
符号 GHS08
GHS08
信号词 Danger

 阿奇霉素用途


用途一:大环内酯类抗菌素,15元含氮杂环,抗菌机理和红霉素相似,但抗菌谱更广。对革兰阳性菌的抗菌活性更强,对革兰阴性菌如流感嗜血杆菌、沙门菌、大肠杆菌、志贺菌等的抗菌活性也较强。且对酸稳定,耐受性好。对敏感菌株引起的呼吸道感染、皮肤软组织感染、性传播性疾病等均有很好的治疗效果。
用途二:为抗生素类药,用于敏感细菌引起的各种感染,如呼吸系统感染、皮肤软组织感染。
用途三:用于呼吸道感染、尿路感染、皮肤及软组织感染和性传播疾病。
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 阿奇霉素名称

[ 中文名 ]: 阿奇霉素
[ 英文名 ]: azithromycin
[中文别名 ]: 阿齐霉素 | 阿奇霉素杂质 B
[英文别名 ]: 更多

 阿奇霉素物理化学性质

[ 密度 ]: 1.2±0.1 g/cm3
[ 沸点 ]: 822.1±65.0 °C at 760 mmHg
[ 熔点 ]: 113-115°C
[ 分子式 ]: C38H72N2O12
[ 分子量 ]: 748.984
[ 闪点 ]: 451.0±34.3 °C
[ 精确质量 ]: 748.508545
[ PSA ]: 180.08000
[ LogP ]: 3.33
[ 外观性状 ]: 白色结晶粉末
[ 蒸汽压 ]: 0.0±0.6 mmHg at 25°C
[ 折射率 ]: 1.537
[ 计算化学 ]:

1、 疏水参数计算参考值(XlogP):4

2、 氢键供体数量:5

3、 氢键受体数量:14

4、 可旋转化学键数量:7

5、 互变异构体数量:

6、 拓扑分子极性表面积(TPSA):180

7、 重原子数量:52

8、 表面电荷:0

9、 复杂度:1150

10、同位素原子数量:0

11、确定原子立构中心数量:18

12、不确定原子立构中心数量:0

13、确定化学键立构中心数量:0

14、不确定化学键立构中心数量:0

15、共价键单元数量:1

[ 更多 ]:

一、物性数据

1. 性状:白色结晶。

2. 密度(g/mL,25/4℃):不确定

3. 相对蒸汽密度(g/mL,空气=1):不确定

4. 熔点(ºC):113~115℃

5. 沸点(ºC,0.67kpa或5 mmHg):不确定

6. 折射率:不确定

7. 闪点(ºC):不确定

8. 比旋光度(ºC):不确定

9. 自燃点或引燃温度(ºC)不确定

10. 蒸气压(kPa,25ºC):不确定

11. 饱和蒸气压(kPa,60ºC):不确定

12. 燃烧热(KJ/mol):不确定

13. 临界温度(ºC):50.3

14. 临界压力(KPa):不确定

15. 油水(辛醇/水)分配系数的对数值:不确定

16. 爆炸上限(%,V/V):不确定

17. 爆炸下限(%,V/V):不确定

18. 溶解性:不确定。

 阿奇霉素毒性和生态

阿奇霉素毒理学数据:

1、急性毒性:人类经口TDLo:32 mg/kg/9D-I;人类经口TDLo:21 mg/kg/3D-I;大鼠经口LD50:>2mg/kg;大鼠腹膜腔LDLo:900mg/kg;小鼠经口LD50:3mg/kg;小鼠腹膜腔LDLo:400mg/kg;

2、其他多剂量毒性:大鼠经口TDLo:3600 mg/kg/36D-I;狗经口TDLo:3600 mg/kg/36D-I;

狗经口TDLo:6100 mg/kg/61D-I;

3、生殖毒性:受孕年5-21天的大鼠经口TDLo:1350 mg/kgSEX/DURATION;

阿奇霉素毒性英文版

 阿奇霉素安全信息

[ 符号 ]: GHS08
GHS08
[ 信号词 ]: Danger
[ 危害声明 ]: H317-H334
[ 警示性声明 ]: P261-P280-P342 + P311
[ 个人防护装备 ]: Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ 危害码 (欧洲) ]: Xi: Irritant;
[ 危险品运输编码 ]: NONH for all modes of transport
[ RTECS号 ]: RN6960000
[ 海关编码 ]: 2941500000

 阿奇霉素合成线路

甲醛结构式

CAS#:50-00-0

甲醛

阿奇霉素 A结构式

CAS#:76801-85-9

阿奇霉素 A

~88%

阿奇霉素结构式

CAS#:83905-01-5

阿奇霉素

文献:KOPRAN RESEARCH LABORATORIES LTD Patent: WO2007/15265 A2, 2007 ; Location in patent: Page/Page column 12-13 ;
结构式

CAS#:1148112-33-7

~89%

阿奇霉素结构式

CAS#:83905-01-5

阿奇霉素

文献:Kim, Hyoung Cheul; Kang, Sung Ho Angewandte Chemie - International Edition, 2009 , vol. 48, # 10 p. 1827 - 1829
甲醛结构式

CAS#:50-00-0

甲醛

~%

阿奇霉素结构式

CAS#:83905-01-5

阿奇霉素

文献:WO2007/80507 A2, ; Page/Page column 12 ;
甲醛结构式

CAS#:50-00-0

甲醛

甲酸结构式

CAS#:64-18-6

甲酸

~%

阿奇霉素结构式

CAS#:83905-01-5

阿奇霉素

文献:Tetrahedron, , vol. 53, # 50 p. 16923 - 16944

 阿奇霉素制备

以红霉素A为原料,经肟化后,在盐酸作用下进行Beckmann重排,再脱水、还原、甲基化可得阿奇霉素。

 阿奇霉素海关

[ 海关编码 ]: 2941500000

 阿奇霉素文献141

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PLoS ONE 10 , e0132791, (2015)

Recently, extracts of Dalbergia trichocarpa bark have been shown to disrupt P. aeruginosa PAO1 quorum sensing (QS) mechanisms, which are key regulators of virulence factor expression and implicated in...

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Biochim. Biophys. Acta 1840(9) , 2851-61, (2014)

Gram-positive bacteria in the phylum Firmicutes synthesize the low molecular weight thiol bacillithiol rather than glutathione or mycothiol. The bacillithiol transferase YfiT from Bacillus subtilis wa...

 阿奇霉素英文别名

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranoside
6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranoside
N-Methyl-11-aza-10-deoxo-10-dihydroerythromycin A
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-{[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-2-ethyl-3,4,10-trihydroxy-13-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-on
Azithromycin
Ribotrex
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,
2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranoside
MFCD00873574
Tobil
Zistic
Azithral
Arzomicin
Zithromac
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl
xz405
Aztrin
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-2-ethyl-3,4,10-trihydroxy-13-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one
Setron
1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-b η-D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-{[(2S,3R,4S,6R)-4-(diméthylamino)-3-hydroxy-6-méthyltétrahydro-2H-pyran-2-yl]oxy}-2-éthyl-3,4,10-trihydroxy-13-{[(2R,4R,5S,6S)-5-hydroxy-4-méthoxy-4,6-diméthyltétrahydro-2H-pyran-2-yl]oxy}-3,5,6,8,10,12,14-heptaméthyl-1-oxa-6-azacyclopentadécan-15-one
Aruzilina
Zeto
1-oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-
Azadose
Aziwok
Azimin
Azenil
9-Deoxo-9a-methyl-9a-aza-9a-homoerythromycin A
azithromycinum [INN_la]
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranoside
XZ-450
Zifin
Ultreon
1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-
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参考价格:$66/10mM*1mLinDMSO

更多阿奇霉素价格

相关知识:

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导读:阿奇霉素(Azithromycin, /əˌzɪθroʊˈmaɪsᵻn/ )是一种属于大环内酯的抗生素,于1980年被发现,1981年推出。又翻译作阿红霉素、阿齐红霉素。阿奇霉素是Azalid...