Phortress free base

• 常用名: Phortress free base
• 英文名: Phortress free base
• CAS号: 741241-36-1
• 分子量: 386.49
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₃FN₄OS
• 熔点: N/A
• 闪点: N/A

Phortress free base用途

Phortress free base (NSC 710305)是一种 P450 CYP1A1 激活的抗肿瘤前药,具有抗肿瘤活性。Phortress free base导致DNA损伤和细胞周期停滞。

Phortress free base名称

• 英文名: Phortress free base

Phortress free base生物活性

• 描述: Phortress free base (NSC 710305)是一种 P450 CYP1A1 激活的抗肿瘤前药,具有抗肿瘤活性。Phortress free base导致DNA损伤和细胞周期停滞。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450
• 参考文献:

  [1]. Behrsing HP, et al. In vitro exposure of precision-cut lung slices to 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole lysylamide dihydrochloride (NSC 710305, Phortress) increases inflammatory cytokine content and tissue damage. Toxicol Sci. 2013 Feb;131(2):470-9.

  [2]. Trapani V, et al. DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells. Br J Cancer. 2003 Feb 24;88(4):599-605.

Phortress free base物理化学性质

• 分子式: C₂₀H₂₃FN₄OS
• 分子量: 386.49