(2R,3R,4R,5S)-2-羟甲基-3,4,5-三羟基哌啶盐酸盐

更新时间：2024-01-02 13:37:00

(2R,3R,4R,5S)-2-羟甲基-3,4,5-三羟基哌啶盐酸盐结构式	常用名	(2R,3R,4R,5S)-2-羟甲基-3,4,5-三羟基哌啶盐酸盐	英文名	1-Deoxynojirimycin hydrochloride
	CAS号	73285-50-4	分子量	199.633
	密度	1.456 g/cm3	沸点	361.1ºC at 760 mmHg
	分子式	C₆H₁₄ClNO₄	熔点	195-196ºC
	MSDS	美版	闪点	197.3ºC

用途

1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) 是一种口服有效的 α-葡萄糖苷酶 (α-glucosidase) 抑制剂。1-Deoxynojirimycin hydrochloride 抑制餐后血糖,预防糖尿病。1-Deoxynojirimycin hydrochloride 具有降血糖、减肥和抗病毒的作用。

中文名	去氧野艽霉素盐酸盐
英文名	Deoxynojirimycin hydrochloride
英文别名	更多

描述	1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) 是一种口服有效的 α-葡萄糖苷酶 (α-glucosidase) 抑制剂。1-Deoxynojirimycin hydrochloride 抑制餐后血糖,预防糖尿病。1-Deoxynojirimycin hydrochloride 具有降血糖、减肥和抗病毒的作用。
相关类别	信号通路 >> PI3K/Akt/mTOR 信号通路 >> PI3K 研究领域 >> 代谢疾病
体内研究	1-脱氧野吉霉素盐酸盐(盐酸杜夫格鲁司他)(20-80 mg/kg；静脉注射；每日4周)具有减肥作用[3]。1-脱氧野吉霉素盐酸盐通过激活db/db小鼠骨骼肌胰岛素信号转导PI3K/AKT通路显著提高胰岛素敏感性[3]。动物模型：db/db小鼠[3]剂量：20、40、80mg/kg,静脉注射,每日4周,结果：体重、血糖、血清胰岛素水平显著降低,糖耐量、胰岛素耐量明显改善。
参考文献	[1]. Gao K, et al. 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing. Molecules. 2016 Nov 23;21(11). pii: E1600. [2]. Chaluntorn Vichasilp,et al. Development of high 1-deoxynojirimycin (DNJ) content mulberry tea and use of response surface methodology to optimize tea-making conditions for highest DNJ extraction. LWT - Food Science and Technology. Volume 45, Issue 2, March 2012, Pages 226-232. [3]. Liu Q, et al. 1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice. Molecules. 2015 Dec 4;20(12):21700-14.

密度	1.456 g/cm3
沸点	361.1ºC at 760 mmHg
熔点	195-196ºC
分子式	C₆H₁₄ClNO₄
分子量	199.633
闪点	197.3ºC
精确质量	199.061142
PSA	92.95000
储存条件	2-8°C，保存于惰性气体中

MSDS英文版

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危害码 (欧洲)	Xi: Irritant;
风险声明 (欧洲)	36/38
安全声明 (欧洲)	S22-S24/25
危险品运输编码	NONH for all modes of transport

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