NSC-60339

更新时间：2025-08-27 14:10:51

NSC-60339结构式	常用名	NSC-60339	英文名	NSC-60339
	CAS号	70-09-7	分子量	486.95300
	密度	N/A	沸点	N/A
	分子式	C₂₆H₂₃ClN₆O₂	熔点	N/A
	MSDS	N/A	闪点	N/A

NSC-60339用途

NSC-60339 是外排泵的抑制剂和 AcrAB-TolC 的底物,是聚对苯二甲酸衍生物,是一种潜在的癌症化疗化合物。

中文名	2-氯-N1,N4-双(4-(4,5-二氢-1H-咪唑-2-基)苯基)对苯二甲酰胺
英文名	2-chloro-1-N,4-N-bis[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]benzene-1,4-dicarboxamide
英文别名	更多

描述	NSC-60339 是外排泵的抑制剂和 AcrAB-TolC 的底物,是聚对苯二甲酸衍生物,是一种潜在的癌症化疗化合物。
相关类别	研究领域 >> 癌症研究领域 >> 感染研究领域 >> 炎症/免疫信号通路 >> 抗感染 >> 细菌
体外研究	NSC 60339与7个肿瘤细胞系对邻苯二甲酰胺的敏感性、耐药性或交叉耐药性相关。敏感肿瘤(L1210、L1210/MTX、L1210/ara-C和P815)迅速吸收药物,并在24小时实验期间主要作为脂质结合药物保留。耐药肿瘤L1210/NSC 60339和2个交叉耐药肿瘤P388/VCR和P815/VLB在0.5小时内所需药物与敏感肿瘤相同,但在24小时内有脂质结合药物从这些耐药肿瘤中流出[3]。
参考文献	[1]. D. W. Yesair, et al. Relationship of Phthalanilide-Lipid Complexes to Uptake and Retention of 2-Chloro-4′,4″-di(2-imidazolin-2-yl)terephthalanilide (NSC 60339) by Sensitive and Resistant P388 Leukemia Cells. CANCER RESEARCH 26 Part 1: 202-207, February 1966. [2]. Yesair DW, et al. The retention or efflux of phthalanilide (NSC 60339)-lipid complexes by sensitive or resistant murine tumor cells and Escherichia coli B. Cancer Res. 1968 Feb;28(2):314-9. [3]. Haynes KM, et al. Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli. J Med Chem. 2017 Jul 27;60(14):6205-6219. [4]. Abdali N, et al. Reviving Antibiotics: Efflux Pump Inhibitors That Interact with AcrA, a Membrane Fusion Protein of the AcrAB-TolC Multidrug Efflux Pump. ACS Infect Dis. 2017 Jan 13;3(1):89-98.

分子式	C₂₆H₂₃ClN₆O₂
分子量	486.95300
精确质量	486.15700
PSA	106.98000
LogP	3.21900
InChIKey	UJQGBYRKCZQJJS-UHFFFAOYSA-N
SMILES	O=C(Nc1ccc(C2=NCCN2)cc1)c1ccc(C(=O)Nc2ccc(C3=NCCN3)cc2)c(Cl)c1
储存条件	-20°C

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th...
来源：Johns Hopkins Ion Channel Center
靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago...
来源：The Scripps Research Institute Molecular Screening Center
靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i...
来源：The Scripps Research Institute Molecular Screening Center
靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Single Concentration Validation of Csn-Mediated Deneddylation of Cullin-Ring Ligase U...
来源：Burnham Center for Chemical Genomics
靶标：COP9 signalosome complex subunit 5 [Homo sapiens]
External Id：SBCCG-A995-CSN5-CP-Assay

实验名称：Single concentration validation of Csn-Mediated Deneddylation of Cullin-Ring Ligase H...
来源：Burnham Center for Chemical Genomics
靶标：72 kDa type IV collagenase isoform a preproprotein [Homo sapiens]
External Id：SBCCG-A996-CSN5-MMP2-CP-Assay

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago...
来源：The Scripps Research Institute Molecular Screening Center
靶标：muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
来源：Burnham Center for Chemical Genomics
靶标：N/A
External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);...
来源：ChEMBL
靶标：Staphylococcus aureus
External Id：CHEMBL4296184

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ...
来源：ChEMBL
靶标：Klebsiella pneumoniae
External Id：CHEMBL4296186

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA...
来源：ChEMBL
靶标：Escherichia coli
External Id：CHEMBL4296185

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