B-赤霉醇结构式
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常用名 | B-赤霉醇 | 英文名 | b-Zearalanol |
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CAS号 | 42422-68-4 | 分子量 | 322.396 | |
密度 | 1.2±0.1 g/cm3 | 沸点 | 576.0±50.0 °C at 760 mmHg | |
分子式 | C18H26O5 | 熔点 | 134-137ºC | |
MSDS | 中文版 美版 | 闪点 | 207.9±23.6 °C | |
符号 |
GHS07, GHS08 |
信号词 | Danger |
B-赤霉醇用途Beta-Zearalanol 是由镰刀菌属 Fusarium 产生的一种霉菌毒素,可以在哺乳动物生殖细胞中引起细胞凋亡 (apoptosis) 和氧化应激反应。 Beta-Zearalanol 是玉米赤霉烯酮(ZEA)的衍生物,可以与葡萄糖醛酸 (glucuronic acid) 结合。 |
中文名 | B-赤霉醇 |
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英文名 | (7S,11S)-7,15,17-trihydroxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),15,17-trien-13-one |
中文别名 | B-玉米赤霉醇 |
英文别名 | 更多 |
描述 | Beta-Zearalanol 是由镰刀菌属 Fusarium 产生的一种霉菌毒素,可以在哺乳动物生殖细胞中引起细胞凋亡 (apoptosis) 和氧化应激反应。 Beta-Zearalanol 是玉米赤霉烯酮(ZEA)的衍生物,可以与葡萄糖醛酸 (glucuronic acid) 结合。 |
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相关类别 | |
体外研究 | βeta-zearalenol(0-200μM; 24小时)以剂量依赖性方式抑制BGC增殖,IC50为25μM[1]。βeta-Zearalenol(0-100μM; 72小时)在HepG2细胞中表现出高毒性,IC50为15.2μM,β-ZOL ZEN或β-ZOL α-ZOL具有协同作用,IC50值分别为19.8uM,16.8uM[2]。βeta-Zearalenol(0-10μM; 72小时)对三种研究细胞因子IL-8,IL-1β和TNF-α的抑制作用均高于ZEA或α-Zearalenol[2]。细胞活力测定[2]细胞系:HepG2细胞浓度:0-100μM培养时间:72小时结果:显示用β-ZOL处理的细胞活力的剂量依赖性降低。细胞增殖测定[1]细胞系:BGC细胞浓度:0μM,5μM,10μM,15μM,25μM,50μM,100μM和200μM培养时间:24小时结果:以剂量依赖性方式抑制细胞增殖。RT-PCR[2]细胞系:HepG2细胞浓度:1μM,5μM,10μM培养时间:72小时结果:与α-玉米赤霉烯醇相比,具有更高的细胞毒性作用。 |
参考文献 |
密度 | 1.2±0.1 g/cm3 |
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沸点 | 576.0±50.0 °C at 760 mmHg |
熔点 | 134-137ºC |
分子式 | C18H26O5 |
分子量 | 322.396 |
闪点 | 207.9±23.6 °C |
精确质量 | 322.178009 |
PSA | 86.99000 |
LogP | 3.86 |
外观性状 | 固体 |
蒸汽压 | 0.0±1.7 mmHg at 25°C |
折射率 | 1.536 |
储存条件 | −20°C |
符号 |
GHS07, GHS08 |
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信号词 | Danger |
危害声明 | H315-H319-H335-H360 |
警示性声明 | P201-P261-P305 + P351 + P338-P308 + P313 |
个人防护装备 | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
危害码 (欧洲) | T,Xn,F |
风险声明 (欧洲) | 60-36/37/38 |
安全声明 (欧洲) | 53-36/37/39-45 |
危险品运输编码 | UN 1648 3 / PGII |
WGK德国 | 3 |
~% B-赤霉醇 42422-68-4 |
文献:Hellwig, Veronika; Mayer-Bartschmid, Anke; Mueller, Hartwig; Greif, Gisela; Kleymann, Gerald; Zitzmann, Werner; Tichy, Hans-Volker; Stadler, Marc Journal of Natural Products, 2003 , vol. 66, # 6 p. 829 - 837 |
~49% B-赤霉醇 42422-68-4 |
文献:El-Sharkawy, Saleh H.; Abul-Hajj, Yusuf J. Journal of Organic Chemistry, 1988 , vol. 53, # 3 p. 515 - 519 |
~% B-赤霉醇 42422-68-4 |
文献:Gelo, Mirjana; Sunjic, Vitomir Tetrahedron, 1992 , vol. 48, # 31 p. 6511 - 6520 |
~% B-赤霉醇 42422-68-4 |
文献:Gelo, Mirjana; Sunjic, Vitomir Tetrahedron, 1992 , vol. 48, # 31 p. 6511 - 6520 |
B-赤霉醇上游产品 4 | |
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B-赤霉醇下游产品 0 |
Determination of resorcylic acid lactones in biological samples by GC-MS. Discrimination between illegal use and contamination with fusarium toxins.
Anal. Bioanal. Chem 384(5) , 1221-7, (2006) An EU project, FAIR5-CT-1997-3443, has been undertaken to distinguish illegal use of zeranol from consumption of food contaminated with Fusarium spp. toxin. One of the tasks was development of screeni... |
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Cytosol protein regulation in H295R steroidogenesis model induced by the zearalenone metabolites, α- and β-zearalenol.
Toxicon 59(1) , 17-24, (2012) α- and β-zearalenol (α-ZOL and β-ZOL, respectively) are metabolites of the mycotoxin zearalenone (ZEN). All three individual mycotoxins have shown to be biological active i.e. being estrogenic and abl... |
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Determination of the cross-reactivities for alpha-zearalenol, beta-zearalenol, zearalanone, alpha-zearalanol, and beta-zearalanol on three commercial immunoaffinity columns targeting zearalenone.
J. AOAC Int. 90(4) , 1197-202, (2007) Immunoaffinity extraction has become increasingly important as a sample preparation and cleanup method in mycotoxin analysis. In this study, the antibody specificities of 3 commercial immunoaffinity c... |
|A-Zearanol |
Taleranol |
(6S,10S)-6-(6,10-Dihydroxyundecyl)-b-resorcyclic acid m-lactone |
1H-2-Benzoxacyclotetradecin-1-one, 3,4,5,6,7,8,9,10,11,12-decahydro-7,14,16-trihydroxy-3-methyl-, (3S,7S)- |
|A-Zearalanol |
Taleranolum |
|A-Zeranol |
(6S,10S)-6-(6,10-Dihydroxyundecyl)-β-resorcyclic acid μ-lactone |
β-Zearalanol |
β zearalanol |
b-Zearalanol |
(3S,7S)-3,4,5,6,7,8,9 |
(3S,7S)-3,4,5,6,7,8,9,10,11,12-Decahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one |
(3S,7S)-7,14,16-Trihydroxy-3-methyl-3,4,5,6,7,8,9,10,11,12-decahydro-1H-2-benzoxacyclotetradecin-1-one |
[3S-(3R*,7R*)]-3,4,5,6,7,8,9,10,11,12-Decahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one |