Grapiprant

• 常用名: Grapiprant
• 英文名: grapiprant
• CAS号: 415903-37-6
• 分子量: 491.605
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₆H₂₉N₅O₃S
• 熔点: N/A
• 闪点: N/A

Grapiprant用途

Grapiprant是一种选择性EP4受体拮抗剂, 生理配体为前列腺素E2(PGE2)。

Grapiprant名称

• 中文名: Grapiprant
• 英文名: Grapiprant

Grapiprant生物活性

• 描述: Grapiprant是一种选择性EP4受体拮抗剂, 生理配体为前列腺素E2(PGE2)。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Vito VD, et al. Detection and quantification of the selective EP4 receptor antagonist CJ-023423 (grapiprant) in canine plasma by HPLC with spectrofluorimetric detection. J Pharm Biomed Anal. 2016 Jan 25;118:251-8.

  [2]. Rausch-Derra LC, et al. Evaluation of the safety of long-term, daily oral administration of grapiprant, a novel drug for treatment of osteoarthritic pain and inflammation, in healthy dogs. Am J Vet Res. 2015 Oct;76(10):853-9.

  [3]. Rahman MJ, et al. Restoration of the type I IFN-IL-1 balance through targeted blockade of PTGER4 inhibits autoimmunity in NOD mice. JCI Insight. 2018 Feb 8;3(3). pii: 97843.

Grapiprant物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₂₆H₂₉N₅O₃S
• 分子量: 491.605
• 精确质量: 491.199097
• LogP: 4.56
• 折射率: 1.647
• 储存条件: 2-8℃

Grapiprant英文别名

• N-{2-[4-(2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]ethyl}-N'-[(4-methylphenyl)sulfonyl]urea
• CJ-023,423
• MR10A7
• N-({2-[4-(2-Ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]ethyl}carbamoyl)-4-methylbenzenesulfonamide
• grapiprant
• Benzenesulfonamide, N-[[[2-[4-(2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]ethyl]amino]carbonyl]-4-methyl-
• RQ-00000007
• AAT-007
• UNII:J9F5ZPH7NB
• 2-Ethyl-4,6-dimethyl-1-[4-[2-[[[[(4-methylphenyl)sulfonyl]amino]carbonyl]amino]ethyl]phenyl]-1H-imidazo[4,5-c]pyridine