(R)-CR8结构式
|
常用名 | (R)-CR8 | 英文名 | (R)-CR8 |
---|---|---|---|---|
CAS号 | 294646-77-8 | 分子量 | 431.533 | |
密度 | 1.3±0.1 g/cm3 | 沸点 | 671.4±65.0 °C at 760 mmHg | |
分子式 | C24H29N7O | 熔点 | N/A | |
MSDS | 美版 | 闪点 | 359.8±34.3 °C | |
符号 |
GHS07 |
信号词 | Warning |
(R)-CR8用途(R)-CR8 (CR8) 是 Roscovitine 的第二代类似物,是一种有效的 CDK1/2/5/7/9 抑制剂。(R)-CR8 (CR8) 抑制 CDK1/cyclin B (IC50=0.09 μM)、CDK2/cyclin A (0.072 μM)、CDK2/cyclin E (0.041 μM)、CDK5/p25 (0.11 μM)、CDK7/cyclin H (1.1μM)、CDK9/cyclin T (0.18μM) 和 CK1δ/ε (0.4 μM)。(R)-CR8 (CR8) 诱导细胞凋亡并具有神经保护作用。 |
中文名 | (R)-2-((9-异丙基-6-((4-(吡啶-2-基)苄基)氨基)-9H-嘌呤-2-基)氨基)丁醇 |
---|---|
英文名 | (2R)-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]butan-1-ol |
英文别名 | 更多 |
描述 | (R)-CR8 (CR8) 是 Roscovitine 的第二代类似物,是一种有效的 CDK1/2/5/7/9 抑制剂。(R)-CR8 (CR8) 抑制 CDK1/cyclin B (IC50=0.09 μM)、CDK2/cyclin A (0.072 μM)、CDK2/cyclin E (0.041 μM)、CDK5/p25 (0.11 μM)、CDK7/cyclin H (1.1μM)、CDK9/cyclin T (0.18μM) 和 CK1δ/ε (0.4 μM)。(R)-CR8 (CR8) 诱导细胞凋亡并具有神经保护作用。 |
---|---|
相关类别 | |
靶点 |
Cdk1/cyclin B:0.09 μM (IC50) cdk2/cyclin A:0.072 μM (IC50) CDK2/cyclinE:0.041 μM (IC50) Cdk5/p25:0.11 μM (IC50) CDK7/cyclin H:1.1 μM (IC50) CDK9/Cyclin T:0.18 μM (IC50) CK1δ/ε:0.4 μM (IC50) |
参考文献 |
密度 | 1.3±0.1 g/cm3 |
---|---|
沸点 | 671.4±65.0 °C at 760 mmHg |
分子式 | C24H29N7O |
分子量 | 431.533 |
闪点 | 359.8±34.3 °C |
精确质量 | 431.243347 |
PSA | 100.78000 |
LogP | 2.10 |
蒸汽压 | 0.0±2.2 mmHg at 25°C |
折射率 | 1.664 |
储存条件 | 2-8°C,密闭,干燥 |
(R)-CR8上游产品 2 | |
---|---|
(R)-CR8下游产品 0 |
Natural product extracts of the Canadian prairie plant, Thermopsis rhombifolia, have anti-cancer activity in phenotypic cell-based assays.
Nat. Prod. Res. 29 , 1026-34, (2015) Many plant species within the terrestrial ecological zones of Canada have not yet been investigated for anti-cancer activity. We examined the scientific literature describing the endemic flora from th... |
|
Substitutions in the Escherichia coli RNA polymerase inhibitor T7 Gp2 that allow inhibition of transcription when the primary interaction interface between Gp2 and RNA polymerase becomes compromised.
Microbiology 158 , 2753-64, (2012) The Escherichia coli-infecting bacteriophage T7 encodes a 7 kDa protein, called Gp2, which is a potent inhibitor of the host RNA polymerase (RNAp). Gp2 is essential for T7 phage development. The inter... |
|
Delayed expression of cell cycle proteins contributes to astroglial scar formation and chronic inflammation after rat spinal cord contusion.
J. Neuroinflammation 9 , 169, (2012) Traumatic spinal cord injury (SCI) induces secondary tissue damage that is associated with astrogliosis and inflammation. We previously reported that acute upregulation of a cluster of cell-cycle-rela... |
(2R)-2-[(9-Isopropyl-6-{[4-(2-pyridinyl)benzyl]amino}-9H-purin-2-yl)amino]-1-butanol |
3ddp |
CR-8 |
HMS3229B13 |
1-Butanol, 2-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-, (2R)- |