3-甲基-2-苯基-N-((1S)-1-苯基丙基)喹啉-4-甲酰胺

更新时间：2024-01-08 18:41:11

3-甲基-2-苯基-N-((1S)-1-苯基丙基)喹啉-4-甲酰胺结构式	常用名	3-甲基-2-苯基-N-((1S)-1-苯基丙基)喹啉-4-甲酰胺	英文名	SB-222200
	CAS号	174635-69-9	分子量	380.48200
	密度	1.142g/cm3	沸点	553.5ºC at 760 mmHg
	分子式	C₂₆H₂₄N₂O	熔点	N/A
	MSDS	美版	闪点	288.6ºC

用途

SB 222200是可逆的竞争性人NK受体抑制剂,对hNK-3受体的Ki为4.4 nM,能透过血脑屏障。

中文名	3-甲基-2-苯基-N-((1S)-1-苯基丙基)喹啉-4-甲酰胺
英文名	3-methyl-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide
英文别名	更多

描述	SB 222200是可逆的竞争性人NK受体抑制剂,对hNK-3受体的Ki为4.4 nM,能透过血脑屏障。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经激肽受体信号通路 >> 神经信号通路 >> 神经激肽受体研究领域 >> 神经疾病
参考文献	[1]. Sarau HM, et al. Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist. J Pharmacol Exp Ther. 2000 Oct;295(1):373-81.

密度	1.142g/cm3
沸点	553.5ºC at 760 mmHg
分子式	C₂₆H₂₄N₂O
分子量	380.48200
闪点	288.6ºC
精确质量	380.18900
PSA	41.99000
LogP	6.48220
蒸汽压	2.7E-12mmHg at 25°C
折射率	1.633
储存条件	2-8℃

MSDS英文版

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport

Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist.

J. Pharmacol. Exp. Ther. 295(1) , 373-81, (2000)

The pharmacological and pharmacokinetic profile of SB-222200 [(S)-(-)-N-(alpha-ethylbenzyl)-3-methyl-2-phenylquinoline-4-car boxami de], a human NK-3 receptor (hNK-3R) antagonist, was determined. SB-2...

In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists.

Br. J. Pharmacol. 122 , 469-476, (1997)

1. Inhibition of NK3 receptor agonist-induced contraction in the rabbit isolated iris sphincter muscle was used to assess the in vitro functional activity of three 2-phenyl-4-quinolinecarboxamides, me...

Expression of neurokinin B/NK3 receptor and kisspeptin/KISS1 receptor in human granulosa cells.

Hum. Reprod. 29(12) , 2736-46, (2014)

Are neurokinin B (NKB), NK3 receptor (NK3R), kisspeptin (KISS1) and kisspeptin receptor (KISS1R) expressed in human ovarian granulosa cells?The NKB/NK3R and kisspeptin/KISS1R systems are co-expressed ...

Lopac-S-5192

Tocris-1393

SB-222200