安帕来斯

• 常用名: 安帕来斯
• 英文名: Ampalex
• CAS号: 154235-83-3
• 分子量: 241.288
• 密度: 1.2±0.1 g/cm3
• 沸点: 433.1±25.0 °C at 760 mmHg
• 分子式: C₁₄H₁₅N₃O
• 熔点: 88-90ºC
• 闪点: 215.8±23.2 °C
• 符号: GHS07
• 信号词: Warning

安帕来斯用途

Ampalex (Ampakine CX516; CX516; BDP 12)是AMPA受体阳性变构调节剂,可作用于阿尔茨海默病,精神分裂等。

安帕来斯名称

• 中文名: 安帕来斯
• 英文名: Piperidin-1-yl(quinoxalin-6-yl)methanone
• 中文别名: 1-(喹喔啉-6-基甲酰基)哌啶 | 6-1-(喹喔啉基-6-羰基)-哌啶

安帕来斯生物活性

• 描述: Ampalex (Ampakine CX516; CX516; BDP 12)是AMPA受体阳性变构调节剂,可作用于阿尔茨海默病,精神分裂等。
• 相关类别:
  信号通路 >> 跨膜转运 >> iGluR
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Broberg BV, Glenth?j BY, Dias R, et al. Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia--sub-chronic and early postnatal PCP treatment in attentional set-shifting. Psychopharmacology (Berl). 2009

  [2]. Kanju PM, Parameshwaran K, Sims C, et al. Ampakine CX516 ameliorates functional deficits in AMPA receptors in a hippocampal slice model of protein accumulation. Exp Neurol. 2008 Nov;214(1):55-61.

  [3]. Goff DC, Lamberti JS, Leon AC, et al. A placebo-controlled add-on trial of the Ampakine, CX516, for cognitive deficits in schizophrenia. Neuropsychopharmacology. 2008 Feb;33(3):465-72.

  [4]. O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets. 2007 May;8(5):603-20.

  [5]. Johnson SA, Simmon VF. Randomized, double-blind, placebo-controlled international clinical trial of the Ampakine CX516 in elderly participants with mild cognitive impairment: a progress report. J Mol Neurosci. 2002 Aug-Oct;19(1-2):197-200.

安帕来斯物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 433.1±25.0 °C at 760 mmHg
• 熔点: 88-90ºC
• 分子式: C₁₄H₁₅N₃O
• 分子量: 241.288
• 闪点: 215.8±23.2 °C
• 精确质量: 241.121506
• PSA: 46.09000
• LogP: 0.57
• InChIKey: ANDGGVOPIJEHOF-UHFFFAOYSA-N
• SMILES: O=C(c1ccc2nccnc2c1)N1CCCCC1
• 外观性状: 黄褐色固体
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.640
• 储存条件: 2~8℃

安帕来斯安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 危害码 (欧洲): Xi
• 危险品运输编码: NONH for all modes of transport
• RTECS号: TM2785170
• 海关编码: 2933990090

安帕来斯海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

安帕来斯英文别名

• Methanone, 1-piperidinyl-6-quinoxalinyl-
• piperidin-1-yl(quinoxalin-6-yl)methanone
• 1-Piperidinyl(6-quinoxalinyl)methanone
• 1-(quinoxalin-6-ylcarbonyl)piperidine
• Ampalex
• BDP-12