玛格斑蝎毒素结构式
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常用名 | 玛格斑蝎毒素 | 英文名 | Margatoxin |
|---|---|---|---|---|
| CAS号 | 145808-47-5 | 分子量 | N/A | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C178H286N52O50S7 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
玛格斑蝎毒素用途Margatoxin 是一种 α-KTx 蝎毒素,一种高亲和力的 Kv1.3 抑制剂,Kd 为 11.7 pM。Margatoxin 抑制 Kv1.2 和 Kv1.1 通道,Kd 值分别为 6.4 pM,4.2 nM。Margatoxin 是一种 39 个氨基酸的肽,是从玛格丽特蝎 (Centruroides margaritatus) 蝎毒中分离得到的,广泛用于离子通道研究。 |
| 中文名 | 玛格斑蝎毒素 |
|---|---|
| 英文名 | Margatoxin |
| 描述 | Margatoxin 是一种 α-KTx 蝎毒素,一种高亲和力的 Kv1.3 抑制剂,Kd 为 11.7 pM。Margatoxin 抑制 Kv1.2 和 Kv1.1 通道,Kd 值分别为 6.4 pM,4.2 nM。Margatoxin 是一种 39 个氨基酸的肽,是从玛格丽特蝎 (Centruroides margaritatus) 蝎毒中分离得到的,广泛用于离子通道研究。 |
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| 相关类别 | |
| 靶点 |
Kd: 11.7 pM (Kv1.3), 6.4 pM (Kv1.2) and 4.2 nM (Kv1.1)[1] |
| 体内研究 | Margatoxin(i.p.；1pmol/g)显著降低12周龄C57BL6/J小鼠腹腔内由硫草胺诱导的白细胞迁移[2]。 |
| 参考文献 |
| 分子式 | C178H286N52O50S7 |
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| 个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| 安全声明 (欧洲) | 22 |
| 危险品运输编码 | NONH for all modes of transport |
| WGK德国 | 3 |
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Evidence for aconitine-induced inhibition of delayed rectifier K(+) current in Jurkat T-lymphocytes.
Toxicology 289(1) , 11-8, (2011) Aconitine (ACO) is a highly toxic diterpenoid alkaloid and known to exert the immunomodulatory action. However, whether it has any effects on ion currents in immune cells remains unknown. The effects ... |
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Charybdotoxin and margatoxin acting on the human voltage-gated potassium channel hKv1.3 and its H399N mutant: an experimental and computational comparison.
J. Phys. Chem. B 116(17) , 5132-40, (2012) The effect of the pore-blocking peptides charybdotoxin and margatoxin, both scorpion toxins, on currents through human voltage-gated hK(v)1.3 wild-type and hK(v)1.3_H399N mutant potassium channels was... |
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Contribution of Kv2.1 channels to the delayed rectifier current in freshly dispersed smooth muscle cells from rabbit urethra.
Am. J. Physiol. Cell Physiol. 301(5) , C1186-200, (2011) We have characterized the native voltage-dependent K(+) (K(v)) current in rabbit urethral smooth muscle cells (RUSMC) and compared its pharmacological and biophysical properties with K(v)2.1 and K(v)2... |
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