希伯胺

更新时间:2024-01-02 17:21:24

希伯胺结构式
希伯胺结构式
品牌特惠专场
常用名 希伯胺 英文名 Xipamide
CAS号 14293-44-8 分子量 354.809
密度 1.5±0.1 g/cm3 沸点 N/A
分子式 C15H15ClN2O4S 熔点 255-256ºC
MSDS 中文版 美版 闪点 N/A
符号 GHS07
GHS07
信号词 Warning

 希伯胺用途


Xipamide 是一种磺胺类利尿剂。Xipamide 是一种能选择性抑制阴离子交换剂 (AE) 的降压药。

 希伯胺名称

中文名 利多速尿
英文名 4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide
中文别名 5-(氨基磺酰基)-4-氯-N-(2,6-二甲基苯基)-2-羟基苯甲酰胺 | 希伯胺
英文别名 更多

 希伯胺物理化学性质

密度 1.5±0.1 g/cm3
熔点 255-256ºC
分子式 C15H15ClN2O4S
分子量 354.809
精确质量 354.044098
PSA 117.87000
LogP 2.50
折射率 1.653
储存条件 Refrigerator
计算化学

1.疏水参数计算参考值(XlogP):2.9

2.氢键供体数量:3

3.氢键受体数量:5

4.可旋转化学键数量:3

5.互变异构体数量:7

6.拓扑分子极性表面积:118

7.重原子数量:23

8.表面电荷:0

9.复杂度:526

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

 希伯胺毒性和生态

 希伯胺安全信息

符号 GHS07
GHS07
信号词 Warning
危害声明 H315-H319-H335
警示性声明 P261-P305 + P351 + P338
危害码 (欧洲) Xi
风险声明 (欧洲) 36/37/38
安全声明 (欧洲) 26
危险品运输编码 NONH for all modes of transport
海关编码 2935009090

 希伯胺海关

海关编码 2935009090
中文概述 2935009090 其他磺(酰)胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
申报要素 品名, 成分含量, 用途
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

 希伯胺文献25

更多文献
Clinicopharmacological reappraisal of the potency of diuretics.

Cardiovasc. Drugs Ther. 7 Suppl 1 , 23-8, (1993)

From a clinicopharmacological standpoint, the urinary excretory potency of diuretics should be assessed comparatively on the basis of the changes in 24-hour natriuresis, with respect to 24-hour natriu...

Bioavailability study of triamterene and xipamide using urinary pharmacokinetic data following single oral dose of each drug or their combination.

J. Pharm. Biomed. Anal. 61 , 78-85, (2012)

An efficient chromatographic method for the simultaneous determination of triamterene (TRI) and xipamide (XIP) in urine samples, based on high performance liquid chromatography with photodiode array d...

Spectrophotometric and spectrodensitometric determination of triamterene and xipamide in pure form and in pharmaceutical formulation.

Drug Test. Anal. 2(3) , 113-21, (2010)

Sensitive and validated UV-spectrophotometric, chemometric and TLC-densitometric methods were developed for determination of triamterene (TRM) and xipamide (XIP) in their binary mixture, formulated fo...

 希伯胺英文别名

Benzamide, 5-(aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-
Xipamide
EINECS 238-216-4
Aquaphor
4-Chloro-2',6'-dimethyl-5-sulfamoylsalicylanilide
4-Chloro-5-sulfamylsalicyloyl-2',6'-dimethylanilide
Xipamid
5-(Aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-benzamide
4-Chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide
Zipix
Aquaphoril
4-chloro-2',6-dimethyl-5-sulfamoylsalicylanilide
Diurexan
5-(aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxybenzamide
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