盐酸沙格雷酯

• 常用名: 盐酸沙格雷酯
• 英文名: Sarpogrelate Hydrochloride
• CAS号: 135159-51-2
• 分子量: 465.967
• 密度: N/A
• 沸点: 585.9ºC at 760 mmHg
• 分子式: C₂₄H₃₂ClNO₆
• 熔点: 145-148°C
• 闪点: 308.1ºC
• 符号: GHS07, GHS09
• 信号词: Warning

盐酸沙格雷酯用途

Sarpogrelate(MCI-9042)盐酸盐是5-HT2拮抗剂,可用作抗血小板类化合物。

盐酸沙格雷酯名称

• 中文名: 盐酸沙格雷酯
• 英文名: Sarpogrelate Hydrochloride
• 中文别名: 沙格雷酯盐酸盐 | (+/-)-2-(二甲胺基)-1-{[2-(3-甲氧基苯基)苯氧基]甲基}乙基丁二酸单酯盐酸盐

盐酸沙格雷酯生物活性

• 描述: Sarpogrelate(MCI-9042)盐酸盐是5-HT2拮抗剂,可用作抗血小板类化合物。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Nishio, H., A. Inoue, and Y. Nakata, Binding affinity of sarpogrelate, a new antiplatelet agent, and its metabolite for serotonin receptor subtypes. Arch Int Pharmacodyn Ther, 1996. 331(2): p. 189-202.

  [2]. Pertz, H. and S. Elz, In-vitro pharmacology of sarpogrelate and the enantiomers of its major metabolite: 5-HT2A receptor specificity, stereoselectivity and modulation of ritanserin-induced depression of 5-HT contractions in rat tail artery. J Pharm Pharma

  [3]. Miyazaki, M., et al., Sarpogrelate hydrochloride, a selective 5-HT2A antagonist, improves vascular function in patients with peripheral arterial disease. J Cardiovasc Pharmacol, 2007. 49(4): p. 221-7.

盐酸沙格雷酯物理化学性质

• 沸点: 585.9ºC at 760 mmHg
• 熔点: 145-148°C
• 分子式: C₂₄H₃₂ClNO₆
• 分子量: 465.967
• 闪点: 308.1ºC
• 精确质量: 465.191803
• PSA: 85.30000
• LogP: 3.99940
• InChIKey: POQBIDFFYCYHOB-UHFFFAOYSA-N
• SMILES: COc1cccc(CCc2ccccc2OCC(CN(C)C)OC(=O)CCC(=O)O)c1.Cl
• 蒸汽压: 1.43E-14mmHg at 25°C
• 储存条件: Desiccate at RT

盐酸沙格雷酯毒性和生态

盐酸沙格雷酯安全信息

• 符号: GHS07, GHS09
• 信号词: Warning
• 危害声明: H302-H400
• 警示性声明: P273
• 危害码 (欧洲): Xn,N
• 风险声明 (欧洲): 22-50/53
• 安全声明 (欧洲): 60-61
• 危险品运输编码: UN 3077 9 / PGIII

盐酸沙格雷酯英文别名

• Butanedioic acid, mono(2-(dimethylamino)-1-((2-(2-(3-methoxyphenyl)ethyl)phenoxy)methyl)ethyl) ester, hydrochloride
• 4-[1-(dimethylamino)-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]propan-2-yl]oxy-4-oxobutanoic acid,hydrochloride
• Butanedioic acid, mono[2-(dimethylamino)-1-[[2-[2-(3-methoxyphenyl)ethyl]phenoxy]methyl]ethyl] ester, hydrochloride (1:1)
• 4-{[1-(Dimethylamino)-3-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}propan-2-yl]oxy}-4-oxobutanoic acid hydrochloride (1:1)
• 4-{[1-(Dimethylamino)-3-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}-2-propanyl]oxy}-4-oxobutanoic acid hydrochloride (1:1)
• UNII:FQN8N8QP1B
• Sarpogrelate HCl
• Sarpogrelate (hydrochloride)