托卡朋

• 常用名: 托卡朋
• 英文名: Tolcapone
• CAS号: 134308-13-7
• 分子量: 273.241
• 密度: 1.4±0.1 g/cm3
• 沸点: 485.6±45.0 °C at 760 mmHg
• 分子式: C₁₄H₁₁NO₅
• 熔点: 126-128ºC
• 闪点: 205.7±17.2 °C
• 符号: GHS09
• 信号词: Warning

托卡朋用途

Tolcapone(Ro 40-7592)是口服活性的外周和中枢COMT抑制剂。

托卡朋名称

• 中文名: 托卡朋
• 英文名: (3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone
• 中文别名: 甲磺酸达氟沙星.甲达沙星.甲磺酸丹诺沙星 | (3,4-二羟基-5-硝基苯基)-(4-甲基苯基)甲酮

托卡朋生物活性

• 描述: Tolcapone(Ro 40-7592)是口服活性的外周和中枢COMT抑制剂。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> COMT
  信号通路 >> 神经信号通路 >> COMT
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Neil E. Paterson, Jennifer Ricciardi, Caitlin Wetzler, et al. Sub-optimal performance in the 5-choice serial reaction time task in rats was sensitive to methylphenidate, atomoxetine and d-amphetamine, but unaffected by the COMT inhibitor tolcapone. Neuros

  [2]. Saviana Di Giovanni, Simona Eleuteri, Katerina E. Paleologou, et al. Entacapone and Tolcapone, Two Catechol O-Methyltransferase Inhibitors, Block Fibril Formation of α-Synuclein and β-Amyloid and Protect against Amyloid-induced Toxicity. The Journal of Bi

  [3]. Panos Bitsios, Panos Roussos1. Tolcapone, COMT polymorphisms and pharmacogenomic treatment of schizophrenia. Pharmacogenomics. 2001,12 (4): 559-566.

  [4]. M.A. Vieira-Coelho, P. Soares-da-Silva. Ontogenic aspects of liver and kidney catechol-O- methyltransferase sensitivity to tolcapone. British Journal of Pharmacology.1996,117 (3):516-520.

  [5]. J. Dingemanse, K. Jorga, G. Zurcher,et al. Pharmacokinetic-pharmacodynamic interaction between the COMT inhibitor tolcapone and single-dose levodopa. British Journal of Clinical Pharmacology 1995, 40 (3):253-262.

托卡朋物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 485.6±45.0 °C at 760 mmHg
• 熔点: 126-128ºC
• 分子式: C₁₄H₁₁NO₅
• 分子量: 273.241
• 闪点: 205.7±17.2 °C
• 精确质量: 273.063721
• PSA: 103.35000
• LogP: 4.07
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.661
• 储存条件: -20°C Freezer

托卡朋毒性和生态

托卡朋安全信息

• 符号: GHS09
• 信号词: Warning
• 危害声明: H400
• 警示性声明: P273
• 危害码 (欧洲): N
• 风险声明 (欧洲): 50
• 安全声明 (欧洲): 61
• 危险品运输编码: UN 3077 9 / PGIII
• RTECS号: PC4952500

托卡朋英文别名

• UNII-CIF6334OLY
• 1-(3,4-dihydroxy-5-nitrophenyl)-1-(4-methylphenyl)methanone
• tolcapone
• Methanone, (3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)-
• tolcapone [INN_en]
• 3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone
• 4'-methyl-3,4-dihydroxy-5-nitro-benzophenone
• [14C]-Tolcapone
• Tasmar (TN)
• MFCD00866569
• Methanone,(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)
• Tasmar
• (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
• Ro 40-7592