R 80123

• 常用名: R 80123
• 英文名: R 80123
• CAS号: 133718-30-6
• 分子量: 459.540
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₆H₂₉N₅O₃
• 熔点: N/A
• 闪点: N/A

R 80123用途

R 80123是R 79595的Z异构体，也是一个高的选则性的phosphodiesterase的抑制剂，他的作用和(HY-100615, Revizinone) R 80122相似。

R 80123名称

• 中文名: R 80123
• 英文名: R 80123

R 80123生物活性

• 描述: R 80123是R 79595的Z异构体,也是一个高的选则性的phosphodiesterase的抑制剂,他的作用和(HY-100615, Revizinone) R 80122相似。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Vandeplassche GM et al. Comparative effects of R 80122, enoximone, and milrinone on left ventricular phosphodiesterase isoenzymes in vitro and on contractility of normal and stunned myocardium in vivo in dogs. J Cardiovasc Pharmacol. 1992 May;19(5):714-22.https://www.ncbi.nlm.nih.gov/pubmed/ 1381769

  [2]. Schneider J et al. Cardiac effects of R 79595 and its isomers (R 80122 and R 80123) in an acute heart failure model. A new class of cardiotonic agents with highly selective phosphodiesterase III inhibitory properties. Naunyn Schmiedebergs Arch Pharmacol. 1992 Nov;346(5):563-72.

  [3]. Vandeplassche GM et al. Comparative effects of R 80122, enoximone, and milrinone on left ventricular phosphodiesterase isoenzymes in vitro and on contractility of normal and stunned myocardium in vivo in dogs. J Cardiovasc Pharmacol. 1992 May;19(5):714-22.

R 80123物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₂₆H₂₉N₅O₃
• 分子量: 459.540
• 精确质量: 459.227051
• LogP: 3.22
• 折射率: 1.677
• 储存条件: 2-8℃

R 80123英文别名

• N-Cyclohexyl-N-methyl-2-({(Z)-[(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-7-yl)(phenyl)methylene]amino}oxy)acetamide
• Acetamide, N-cyclohexyl-N-methyl-2-[[[(1Z)-phenyl(1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazolin-7-yl)methylene]amino]oxy]-