R 80123

Modify Date: 2025-08-27 15:20:08

R 80123 Structure
R 80123 structure
Common Name R 80123
CAS Number 133718-30-6 Molecular Weight 459.540
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C26H29N5O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of R 80123


R 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor. The fuction is similar to R 80122 (HY-100615, Revizinone).In vivo: The administration of Revizinone improved the haemodynamic profile with an increase in cardiac output, a decrease in systemic vascular resistance and a stable heart rate and mean arterial blood pressure. [1] With regard to reconstitution of contractility and cardiac function Revizinone (E-isomer) is 10 fold more potent than R 79595 and nearly 100 fold more potent than R 80123 (Z-isomer). [2] Revizinone significantly increases global LV function and systolic wall thickening in ischemic areas at doses greater than or equal to 0.16 mg/kg i.v. [3]

 Names

Name R 80123
Synonym More Synonyms

 R 80123 Biological Activity

Description R 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor. The fuction is similar to R 80122 (HY-100615, Revizinone).In vivo: The administration of Revizinone improved the haemodynamic profile with an increase in cardiac output, a decrease in systemic vascular resistance and a stable heart rate and mean arterial blood pressure. [1] With regard to reconstitution of contractility and cardiac function Revizinone (E-isomer) is 10 fold more potent than R 79595 and nearly 100 fold more potent than R 80123 (Z-isomer). [2] Revizinone significantly increases global LV function and systolic wall thickening in ischemic areas at doses greater than or equal to 0.16 mg/kg i.v. [3]
Related Catalog
References

[1]. Vandeplassche GM et al. Comparative effects of R 80122, enoximone, and milrinone on left ventricular phosphodiesterase isoenzymes in vitro and on contractility of normal and stunned myocardium in vivo in dogs. J Cardiovasc Pharmacol. 1992 May;19(5):714-22.https://www.ncbi.nlm.nih.gov/pubmed/ 1381769

[2]. Schneider J et al. Cardiac effects of R 79595 and its isomers (R 80122 and R 80123) in an acute heart failure model. A new class of cardiotonic agents with highly selective phosphodiesterase III inhibitory properties. Naunyn Schmiedebergs Arch Pharmacol. 1992 Nov;346(5):563-72.

[3]. Vandeplassche GM et al. Comparative effects of R 80122, enoximone, and milrinone on left ventricular phosphodiesterase isoenzymes in vitro and on contractility of normal and stunned myocardium in vivo in dogs. J Cardiovasc Pharmacol. 1992 May;19(5):714-22.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C26H29N5O3
Molecular Weight 459.540
Exact Mass 459.227051
LogP 3.22
Index of Refraction 1.677
Storage condition 2-8℃

 Synonyms

N-Cyclohexyl-N-methyl-2-({(Z)-[(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-7-yl)(phenyl)methylene]amino}oxy)acetamide
Acetamide, N-cyclohexyl-N-methyl-2-[[[(1Z)-phenyl(1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazolin-7-yl)methylene]amino]oxy]-
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